Photoactivatable Ru complexes containing a RuO bond: Photoinduced ligand dissociation and DNA damage

Photoactivatable Ru complexes containing a RuO bond: Photoinduced ligand dissociation and DNA damage Journal of Photochemistry and Photobiology A: Chemistry 355 (2018) 360–365 Contents lists available at ScienceDirect Journal of Photochemistry and Photobiology A: Chemistry journal home page : www.elsevier.com/locat e/jphotochem Invited paper Photoactivatable Ru complexes containing a RuO bond: Photoinduced ligand dissociation and DNA damage a, a,b a,b, * * Qianxiong Zhou , Yue Zheng , Xuesong Wang Key Laboratory of Photochemical Conversion and Optoelectronic Materials, Technical Institute of Physics and Chemistry, Chinese Academy of Sciences, Beijing 100190, PR China Graduate School of Chinese Academy of Sciences, Beijing 100049, PR China A R T I C L E I N F O A B S T R A C T Article history: Received 19 June 2017 Ru complexes bearing photolabile ligands exhibit DNA covalent binding capability upon ligand Received in revised form 7 August 2017 photodissociation and thus show promising application potential as a new type of anticancer agents. Our + 0 Accepted 8 August 2017 recent work has shown that [Ru(bpy) (py-SO )] (complex 1, bpy = 2,2 -bipyridine, py-SO = pyridine-2- 2 3 3 Available online 12 August 2017 sulfonate) can generate py-SO radicals along with the photodissociation of py-SO , leading to DNA 3 3 covalent binding with http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Journal of Photochemistry and Photobiology A: Chemistry Elsevier

Photoactivatable Ru complexes containing a RuO bond: Photoinduced ligand dissociation and DNA damage

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Publisher
Elsevier
Copyright
Copyright © 2017 Elsevier B.V.
ISSN
1010-6030
eISSN
1873-2666
D.O.I.
10.1016/j.jphotochem.2017.08.018
Publisher site
See Article on Publisher Site

Abstract

Journal of Photochemistry and Photobiology A: Chemistry 355 (2018) 360–365 Contents lists available at ScienceDirect Journal of Photochemistry and Photobiology A: Chemistry journal home page : www.elsevier.com/locat e/jphotochem Invited paper Photoactivatable Ru complexes containing a RuO bond: Photoinduced ligand dissociation and DNA damage a, a,b a,b, * * Qianxiong Zhou , Yue Zheng , Xuesong Wang Key Laboratory of Photochemical Conversion and Optoelectronic Materials, Technical Institute of Physics and Chemistry, Chinese Academy of Sciences, Beijing 100190, PR China Graduate School of Chinese Academy of Sciences, Beijing 100049, PR China A R T I C L E I N F O A B S T R A C T Article history: Received 19 June 2017 Ru complexes bearing photolabile ligands exhibit DNA covalent binding capability upon ligand Received in revised form 7 August 2017 photodissociation and thus show promising application potential as a new type of anticancer agents. Our + 0 Accepted 8 August 2017 recent work has shown that [Ru(bpy) (py-SO )] (complex 1, bpy = 2,2 -bipyridine, py-SO = pyridine-2- 2 3 3 Available online 12 August 2017 sulfonate) can generate py-SO radicals along with the photodissociation of py-SO , leading to DNA 3 3 covalent binding with

Journal

Journal of Photochemistry and Photobiology A: ChemistryElsevier

Published: Mar 15, 2018

References

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