Chemical Physics Letters 695 (2018) 59–62 Contents lists available at ScienceDirect Chemical Physics Letters journal homepage: www.elsevier.com/locate/cplett Research paper Photo-physics study of a styrylquinoline as inhibitor of Pim-1 kinase: Solvent and concentration effects a a a,⇑ a a Taibi Lamhasni , Sara Barbache , Saadia Ait Lyazidi , Mustapha Haddad , Mohamed Hnach , Didier Desmaële Laboratoire de Spectrométrie des Matériaux et Archéomatériaux (LASMAR), URAC 11, Université Moulay Ismail, Faculté des Sciences, B.P 11201 Zitoune, Meknes 50000, Morocco UMR, CNRS 8612, Faculté de Pharmacie, Université Paris Sud, 5 rue J.-B. Clément, 92296 Châtenay-Malabry, France article i nfo abstract Article history: 7-Nicotinoyl-styrylquinoline (MB96) displays an antiviral activity on HIV-1 infected CEM cell lines and is Received 19 November 2017 a promising inhibitor of the serine/threonine-protein Pim-1 kinase. By means of UV–vis spectroscopy In ﬁnal form 1 February 2018 supported by theoretical calculations this styrylquinoline is shown to exist in different conformations: Available online 2 February 2018 the s-trans planar conformation along with other twisted ones with respect to the torsion around the sin- gle bond between the quinoline and the phenylethenyl appendage. Hydrogen bonding interactions with Keywords: the solvent shift the skeleton of the MB96 towards the planar form, enhancing
Chemical Physics Letters – Elsevier
Published: Mar 1, 2018
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