Phase shifting the human circadian clock using melatonin

Phase shifting the human circadian clock using melatonin Melatonin is produced only during nighttime darkness. Its onset during the evening is a useful marker for circadian phase position, when melatonin levels are sampled frequenly and under conditions of dim light or darkness. This marker is termed the dim light melatonin onset (DLMO). Recently, we have described a phase response curve (PRC) to melatonin in humans that is about 12 h out of phase with the PRC to light. Exogenous melatonin administration and bright light exposure can be used to shift circadian rhythms according to their respective PRCs. These phase-resetting agents can be used alone or together to treat circadian phase disorders, which include advanced and delayed sleep phase syndrome, shift work maladaptation, jet lag and winter depression. Endogenous melatonin may function to augment entrainment of circadian rhythms by the light-dark cycle. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Behavioural Brain Research Elsevier

Phase shifting the human circadian clock using melatonin

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Publisher
Elsevier
Copyright
Copyright © 1996 Elsevier Ltd
ISSN
0166-4328
DOI
10.1016/0166-4328(96)00084-8
Publisher site
See Article on Publisher Site

Abstract

Melatonin is produced only during nighttime darkness. Its onset during the evening is a useful marker for circadian phase position, when melatonin levels are sampled frequenly and under conditions of dim light or darkness. This marker is termed the dim light melatonin onset (DLMO). Recently, we have described a phase response curve (PRC) to melatonin in humans that is about 12 h out of phase with the PRC to light. Exogenous melatonin administration and bright light exposure can be used to shift circadian rhythms according to their respective PRCs. These phase-resetting agents can be used alone or together to treat circadian phase disorders, which include advanced and delayed sleep phase syndrome, shift work maladaptation, jet lag and winter depression. Endogenous melatonin may function to augment entrainment of circadian rhythms by the light-dark cycle.

Journal

Behavioural Brain ResearchElsevier

Published: Dec 15, 1995

References

  • Melatonin receptors in the mammalian suprachiasmatic nucleus
    Dubocovich, M.; Benloucif, S.; Masana, M.I.
  • Circadian rhythms in lizards: phase response curve for melatonin
    Underwood, H.

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