Phase I combination study of the PARP inhibitor veliparib plus carboplatin and gemcitabine in patients with advanced ovarian cancer and other solid malignancies

Phase I combination study of the PARP inhibitor veliparib plus carboplatin and gemcitabine in... •Phase I study of veliparib+carboplatin/gemcitabine in advanced solid tumors.•MTD/RP2D was veliparib 250mg BID, carboplatin AUC 4, and gemcitabine 800mg/m2.•Thrombocytopenia and neutropenia were the most commonly reported AEs.•Promising antitumor activity in advanced solid tumors with germline BRCA mutations. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Gynecologic Oncology Elsevier

Phase I combination study of the PARP inhibitor veliparib plus carboplatin and gemcitabine in patients with advanced ovarian cancer and other solid malignancies

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Publisher
Elsevier
Copyright
Copyright © 2018 Elsevier Inc.
ISSN
0090-8258
eISSN
1095-6859
D.O.I.
10.1016/j.ygyno.2017.12.029
Publisher site
See Article on Publisher Site

Abstract

•Phase I study of veliparib+carboplatin/gemcitabine in advanced solid tumors.•MTD/RP2D was veliparib 250mg BID, carboplatin AUC 4, and gemcitabine 800mg/m2.•Thrombocytopenia and neutropenia were the most commonly reported AEs.•Promising antitumor activity in advanced solid tumors with germline BRCA mutations.

Journal

Gynecologic OncologyElsevier

Published: Mar 1, 2018

References

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