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Objectives To evaluate the potential benefits of high - dose buprenorphine formulations for analgesia in cats, serial and crossover studies were undertaken to investigate their pharmacokinetics ...
‐dependent patient populations.These models are robust in predicting IV and SL BUP exposure following single and multiple BUP doses up to 32 mg.IntroductionDrug overdose and associated deaths have become ...
Buprenorphine is absorbed following sublingual administration, which would be a low‐stress delivery route in foals. However, the pharmacokinetics /pharmacodynamics are not described in foals. Six ...
Crossref Search ADS PubMed 37 McAleer SD , Mills RJ , Polack T , et al. . Pharmacokinetics of high - dose buprenorphine following single administration of sublingual tablet formulations in opioid naive healthy ...
of the pharmacokinetics of single - and multiple- dose buprenorphine buccal film in healthy volunteers . Clin Ther 2016 ; 38 : 358 – 69 . Google Scholar Crossref Search ADS PubMed 24 Soetaert K , Petzoldt T , Woodrow Setzer ...
) confirm the presence of OIH; 2) ascertain whether very high intravenous morphine doses produce antinociceptive and respiratory depression effects; and 3) determine any relationship between buprenorphine ...
healthy volunteers ( single -blind, randomized) and eight opioid-tolerant patients taking daily opioid doses ≥90 mg oral morphine equivalents (open-label) received continuous intravenous buprenorphine ...
the absolute bioavailability of sublingual doses of 2 mg of buprenorphine in 1 mL of 300 mL/L ethanol and the bioequivalence of sublingual 8-mg tablet and 300 mL/L ethanol solution formulations. Buprenorphine ...
There were no differences in methadone dose requirements or plasma concentrations associated with other CYP mutations. Buprenorphine and buprenorphine –naloxone Pharmacology and pharmacokinetics . Buprenorphine ...
by the number of consecutive opioid-free urine specimens. Buprenorphine three times per week, levomethadyl acetate three times per week, and high - dose methadone daily all led to a greater decrease in illicit ...
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