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contributing to variations in drug responses. Genetic Variations Affecting Drug Response and Toxicity with Cancer Chemotherapy Pharmacogenomic approaches have been applied to many existing chemotherapy agents ...
candidates for predicting anemia after S-1 treatment. S-1, Advanced gastric cancer , Predictive marker, Pharmacokinetics , Pharmacogenomics Introduction Systemic chemotherapy is tried in advanced gastric cancer ...
effects. Introduction Pharmacogenomics (PGx) examines how genetic variants impact pharmacokinetics (e.g. drug-metabolizing enzymes) and pharmacodynamics (e.g. target receptors) properties of specific drugs ...
for patients with HER-2+ AGC. On the other hand, the Avastin® in Gastric Cancer trial evaluating bevacizumab in combination with chemotherapy did not meet its primary endpoint of a longer overall survival ...
cause of death worldwide with approximately 8 million deaths each year. Cancer treatments may include surgery, chemotherapy , radiotherapy, hormone therapy and targeted immunotherapy.[1] In immunotherapy ...
in that study [13]. Similarly, in 175 patients with advanced gastric cancer who received cisplatin and 5-FU combination chemotherapy , GSTT1 deletion did not affect clinical response or survival [15]. In addition ...
with advanced gastric cancer who were untreated with chemotherapy for advanced disease [6]. The study enrolled male and female patients >18 years of age with histologically confirmed, unresectable, locally ...
) gene expression is being carried out at Memorial Sloan Kettering Cancer Center (MSKCC). 5-fluorouracil (5-FU) is a widely used chemotherapy regimen in gastric cancers , but only a small proportion ...
Chabner (Massachusetts General Hospital), focuses on the future of cancer pharmacology [26]. Specifically, Dr. Chabner discusses the use of pharmacogenomics and pharmacogenetics to customize cancer therapy ...
, King CR, Marsh S. Application of pharmacogenomics in the individualization of chemotherapy for gastrointestinal malignancies . Clin Colorectal Cancer 2004 ; 4 ( suppl 1 ): S43 –S47. Google Scholar PubMed ...
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