Carbohydrate Polymers 181 (2018) 841–850 Contents lists available at ScienceDirect Carbohydrate Polymers journal homepage: www.elsevier.com/locate/carbpol pH-responsive selenium nanoparticles stabilized by folate-chitosan delivering doxorubicin for overcoming drug-resistant cancer cells a b c a, Urarika Luesakul , Songchan Puthong , Nouri Neamati , Nongnuj Muangsin Department of Chemistry, Faculty of Science, Chulalongkorn University, Bangkok 10330, Thailand Antibody Production Research Unit, Institute of Biotechnology and Genetic Engineering, Chulalongkorn University, Bangkok 10330, Thailand Department of Medicinal Chemistry, College of Pharmacy, and Translational Oncology Program, University of Michigan, North Campus Research Complex,1600 Huron Parkway, Ann Arbor, MI, 48109, USA ARTICLE I NFO ABSTRACT Keywords: Herein, we ﬁrst report pH-responsive SeNPs stabilized with modiﬁed folic acid-N-trimethyl chitosan (TMC-FA) pH-sensitive as nanocarriers for delivery of doxorubicin (DOX) to overcome drug-resistant cancer cells, which could enhance Selenium nanoparticles the activity of DOX by approximately 10-fold for a reduced IC value compared to free DOX. When nano- Doxorubicin particles were taken up by cells, the DOX-loaded SeNPs@TMC-FA demonstrated a faster release rate under acidic Chitosan conditions. The cumulative release amount of DOX at pH 5.3 was 54.1% within 2 h and 95.5% at 6 h, whereas Multidrug resistance the release rate at pH 7.4 was 12.3% in 2
Carbohydrate Polymers – Elsevier
Published: Feb 1, 2018
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