The kindling effect is generally thought to be highly persistent and possibly permanent, but little direct evidence is available to support this idea. Retention of amygdala kindling was examined after a 12-wk interval in groups of rats that had been electrically kindled to different seizure stages (stages 1, 3, or 5), or kindled by high intensity or low frequency (3 pulses per second) stimulation, or fully kindled and allowed a rest of 1–24 wk. The retention of hippocampal kindling after a 12-wk interval was also examined. Rekindling after a 12-wk rest in the groups initially kindled to different seizure stages indicated that although there was evidence of erosion of the kindling effect in all groups, there were savings in all groups. There was also evidence of greater erosion in the afterdischarge response than in the convulsive response to the first stimulation after the interval. Although there was evidence of erosion of kindling during the 1–24-wk intervals, there was evidence of savings in all groups, none of which required more than a mean of 2.2 afterdischarges to rekindle to stage 5. Seizures kindled in the hippocampus were retained as well as those kindled in the amygdala, and seizures kindled using low frequency stimulation were retained as well as those kindled using conventional 60 pulses per second stimulation. We conclude that the effects of kindling the amygdala and hippocampus are highly persistent, and that the effects of kindling with low frequency stimulation are as persistent as kindling with conventional stimulation.
Epilepsy Research – Elsevier
Published: Jul 1, 1995
It’s your single place to instantly
discover and read the research
that matters to you.
Enjoy affordable access to
over 18 million articles from more than
15,000 peer-reviewed journals.
All for just $49/month
Query the DeepDyve database, plus search all of PubMed and Google Scholar seamlessly
Save any article or search result from DeepDyve, PubMed, and Google Scholar... all in one place.
Get unlimited, online access to over 18 million full-text articles from more than 15,000 scientific journals.
Read from thousands of the leading scholarly journals from SpringerNature, Elsevier, Wiley-Blackwell, Oxford University Press and more.
All the latest content is available, no embargo periods.
“Hi guys, I cannot tell you how much I love this resource. Incredible. I really believe you've hit the nail on the head with this site in regards to solving the research-purchase issue.”Daniel C.
“Whoa! It’s like Spotify but for academic articles.”@Phil_Robichaud
“I must say, @deepdyve is a fabulous solution to the independent researcher's problem of #access to #information.”@deepthiw
“My last article couldn't be possible without the platform @deepdyve that makes journal papers cheaper.”@JoseServera