Article history: Polymeric liposomes (PEG/RGD-MPLs), composed of amphiphilic polymer octadecyl-quaternized mod- Received 9 October 2011 iﬁed poly (-glutamic acid) (OQPGA), PEGylated OQPGA, RGD peptide grafted OQPGA and magnetic Received in revised form nanoparticles, was prepared successfully. These PEG/RGD-MPLs could be used as a multifunctional plat- 15 December 2011 form for targeted drug delivery. The results showed that PEG/RGD-MPLs were multilamellar spheres with Accepted 7 January 2012 nano-size (50–70 nm) and positive surface charge (28–42 mV). Compared with magnetic conventional Available online 14 January 2012 liposomes (MCLs), PEG/RGD-MPLs exhibited sufﬁcient size and zeta potential stability, low initial burst release and less magnetic nanoparticles leakage. The cell uptake results suggested that the PEG/RGD- Keywords: MPLs (with RGD and magnetic particles) exhibited more drug cellular uptake than non RGD and non Drug delivery magnetism carriers in MCF-7 cells. MTT assay revealed that PEG/RGD-MPLs showed lower in vitro cyto- Polymeric liposomes toxicity to GES-1 cells at ≤100 g/mL. These data indicated that the multifunctional PEG/RGD-MPLs may Magnetic nanoparticles Tumor Targeting be an alternative formulation for drug delivery system. RGD peptide © 2012 Elsevier B.V. All rights reserved. 1. Introduction as drug carriers, MDT can guide their accumulation in target tis- sues under strong
International Journal of Pharmaceutics – Elsevier
Published: Apr 15, 2012
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