PEG/RGD-modified magnetic polymeric liposomes for controlled drug release and tumor cell targeting

PEG/RGD-modified magnetic polymeric liposomes for controlled drug release and tumor cell targeting Article history: Polymeric liposomes (PEG/RGD-MPLs), composed of amphiphilic polymer octadecyl-quaternized mod- Received 9 October 2011 ified poly (-glutamic acid) (OQPGA), PEGylated OQPGA, RGD peptide grafted OQPGA and magnetic Received in revised form nanoparticles, was prepared successfully. These PEG/RGD-MPLs could be used as a multifunctional plat- 15 December 2011 form for targeted drug delivery. The results showed that PEG/RGD-MPLs were multilamellar spheres with Accepted 7 January 2012 nano-size (50–70 nm) and positive surface charge (28–42 mV). Compared with magnetic conventional Available online 14 January 2012 liposomes (MCLs), PEG/RGD-MPLs exhibited sufficient size and zeta potential stability, low initial burst release and less magnetic nanoparticles leakage. The cell uptake results suggested that the PEG/RGD- Keywords: MPLs (with RGD and magnetic particles) exhibited more drug cellular uptake than non RGD and non Drug delivery magnetism carriers in MCF-7 cells. MTT assay revealed that PEG/RGD-MPLs showed lower in vitro cyto- Polymeric liposomes toxicity to GES-1 cells at ≤100 g/mL. These data indicated that the multifunctional PEG/RGD-MPLs may Magnetic nanoparticles Tumor Targeting be an alternative formulation for drug delivery system. RGD peptide © 2012 Elsevier B.V. All rights reserved. 1. Introduction as drug carriers, MDT can guide their accumulation in target tis- sues under strong http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png International Journal of Pharmaceutics Elsevier

PEG/RGD-modified magnetic polymeric liposomes for controlled drug release and tumor cell targeting

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Publisher
Elsevier
Copyright
Copyright © 2012 Elsevier B.V.
ISSN
0378-5173
D.O.I.
10.1016/j.ijpharm.2012.01.013
Publisher site
See Article on Publisher Site

Abstract

Article history: Polymeric liposomes (PEG/RGD-MPLs), composed of amphiphilic polymer octadecyl-quaternized mod- Received 9 October 2011 ified poly (-glutamic acid) (OQPGA), PEGylated OQPGA, RGD peptide grafted OQPGA and magnetic Received in revised form nanoparticles, was prepared successfully. These PEG/RGD-MPLs could be used as a multifunctional plat- 15 December 2011 form for targeted drug delivery. The results showed that PEG/RGD-MPLs were multilamellar spheres with Accepted 7 January 2012 nano-size (50–70 nm) and positive surface charge (28–42 mV). Compared with magnetic conventional Available online 14 January 2012 liposomes (MCLs), PEG/RGD-MPLs exhibited sufficient size and zeta potential stability, low initial burst release and less magnetic nanoparticles leakage. The cell uptake results suggested that the PEG/RGD- Keywords: MPLs (with RGD and magnetic particles) exhibited more drug cellular uptake than non RGD and non Drug delivery magnetism carriers in MCF-7 cells. MTT assay revealed that PEG/RGD-MPLs showed lower in vitro cyto- Polymeric liposomes toxicity to GES-1 cells at ≤100 g/mL. These data indicated that the multifunctional PEG/RGD-MPLs may Magnetic nanoparticles Tumor Targeting be an alternative formulation for drug delivery system. RGD peptide © 2012 Elsevier B.V. All rights reserved. 1. Introduction as drug carriers, MDT can guide their accumulation in target tis- sues under strong

Journal

International Journal of PharmaceuticsElsevier

Published: Apr 15, 2012

References

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