Available online at www.sciencedirect.com ScienceDirect Pediatric cardiovascular grafts: historical perspective and future directions 1 2,3 1 Stanley Heydrick , Erin Roberts , Jaeyun Kim , 3 1,2 Sitaram Emani and Joyce Y Wong Tissue-engineered cardiovascular patches, cardiac valves, and anatomical abnormalities, including cardiac septal great vessels are emerging solutions for the surgical treatment defects, valve defects, and/or structural abnormalities in of congenital cardiovascular abnormalities due to their the great arteries and veins. As a result, many of these potential for adapting with the growing child. The ideal pediatric conditions require surgical solutions that involve the cardiovascular patch/graft is non-thrombogenic, implantation of patches, cardiac valves, and portions of phenotypically compatible, and matches the compliance and great vessels. mechanical strength of the native tissue, both initially and throughout growth. Bottom-up tissue engineering approaches, While autografts taken from other parts of the body remain in which three-dimensional tissue is built layer-by-layer from the gold standard for use in surgical reparation of pediatric scaffold-less cell sheets in vitro, offer an exciting potential cardiovascular anomalies, there is frequently a limited solution. Cell source variability, sheet patterning, and scaffold- availability of adequately sized autograft tissue from pedi- less fabrication are promising advantages offered by this
Current Opinion in Biotechnology – Elsevier
Published: Aug 1, 2016
It’s your single place to instantly
discover and read the research
that matters to you.
Enjoy affordable access to
over 18 million articles from more than
15,000 peer-reviewed journals.
All for just $49/month
Query the DeepDyve database, plus search all of PubMed and Google Scholar seamlessly
Save any article or search result from DeepDyve, PubMed, and Google Scholar... all in one place.
Get unlimited, online access to over 18 million full-text articles from more than 15,000 scientific journals.
Read from thousands of the leading scholarly journals from SpringerNature, Elsevier, Wiley-Blackwell, Oxford University Press and more.
All the latest content is available, no embargo periods.
“Hi guys, I cannot tell you how much I love this resource. Incredible. I really believe you've hit the nail on the head with this site in regards to solving the research-purchase issue.”Daniel C.
“Whoa! It’s like Spotify but for academic articles.”@Phil_Robichaud
“I must say, @deepdyve is a fabulous solution to the independent researcher's problem of #access to #information.”@deepthiw
“My last article couldn't be possible without the platform @deepdyve that makes journal papers cheaper.”@JoseServera