Available online at www.sciencedirect.com ScienceDirect Pediatric cardiovascular grafts: historical perspective and future directions 1 2,3 1 Stanley Heydrick , Erin Roberts , Jaeyun Kim , 3 1,2 Sitaram Emani and Joyce Y Wong Tissue-engineered cardiovascular patches, cardiac valves, and anatomical abnormalities, including cardiac septal great vessels are emerging solutions for the surgical treatment defects, valve defects, and/or structural abnormalities in of congenital cardiovascular abnormalities due to their the great arteries and veins. As a result, many of these potential for adapting with the growing child. The ideal pediatric conditions require surgical solutions that involve the cardiovascular patch/graft is non-thrombogenic, implantation of patches, cardiac valves, and portions of phenotypically compatible, and matches the compliance and great vessels. mechanical strength of the native tissue, both initially and throughout growth. Bottom-up tissue engineering approaches, While autografts taken from other parts of the body remain in which three-dimensional tissue is built layer-by-layer from the gold standard for use in surgical reparation of pediatric scaffold-less cell sheets in vitro, offer an exciting potential cardiovascular anomalies, there is frequently a limited solution. Cell source variability, sheet patterning, and scaffold- availability of adequately sized autograft tissue from pedi- less fabrication are promising advantages offered by this
Current Opinion in Biotechnology – Elsevier
Published: Aug 1, 2016
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