Patterns of Failure in Patients With Double Hit or Double Expressor Lymphomas: Implications for Radiation Therapy

Patterns of Failure in Patients With Double Hit or Double Expressor Lymphomas: Implications for... PurposeLymphomas with MYC and either BLC2 or BCL6 rearrangements or MYC and BCL-2 protein overexpression, classified as double-hit (DHL) or double-expressor (DEL) lymphomas, respectively, are associated with poorer response to standard immunochemotherapy. Optimal therapy is not clear, and little information exists on the contribution of consolidative radiation therapy in these patients. This study describes the patterns of failure of DHL/DEL in relation to initial sites of disease and indications for radiation therapy in unselected diffuse large B-cell lymphoma (DLBCL). http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png International Journal of Radiation Oncology Biology Physics Elsevier

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Publisher
Elsevier
Copyright
Copyright © 2018 Elsevier Inc.
ISSN
0360-3016
D.O.I.
10.1016/j.ijrobp.2018.01.041
Publisher site
See Article on Publisher Site

Abstract

PurposeLymphomas with MYC and either BLC2 or BCL6 rearrangements or MYC and BCL-2 protein overexpression, classified as double-hit (DHL) or double-expressor (DEL) lymphomas, respectively, are associated with poorer response to standard immunochemotherapy. Optimal therapy is not clear, and little information exists on the contribution of consolidative radiation therapy in these patients. This study describes the patterns of failure of DHL/DEL in relation to initial sites of disease and indications for radiation therapy in unselected diffuse large B-cell lymphoma (DLBCL).

Journal

International Journal of Radiation Oncology Biology PhysicsElsevier

Published: Apr 1, 2018

References

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