Pathophysiology of diabetic nephropathy

Pathophysiology of diabetic nephropathy Diabetic nephropathy (DN) is now the commonest cause of end-stage renal failure in the Western world. Recent studies examining the pathogenesis of diabetic complications have focused on the complex interaction between genetic and hemodynamic mechanisms in addition to metabolic factors such as advanced glycation, protein kinase C (PKC) activation, and polyol production. The importance of the various components, particularly with regard to the progression of DN, is currently being explored with the assistance of targeted drug intervention studies. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Metabolism Elsevier

Pathophysiology of diabetic nephropathy

Loading next page...
 
/lp/elsevier/pathophysiology-of-diabetic-nephropathy-D3Vc0KUGU0
Publisher
Elsevier
Copyright
Copyright © 1998 Elsevier Ltd
ISSN
0026-0495
DOI
10.1016/S0026-0495(98)90362-6
Publisher site
See Article on Publisher Site

Abstract

Diabetic nephropathy (DN) is now the commonest cause of end-stage renal failure in the Western world. Recent studies examining the pathogenesis of diabetic complications have focused on the complex interaction between genetic and hemodynamic mechanisms in addition to metabolic factors such as advanced glycation, protein kinase C (PKC) activation, and polyol production. The importance of the various components, particularly with regard to the progression of DN, is currently being explored with the assistance of targeted drug intervention studies.

Journal

MetabolismElsevier

Published: Dec 1, 1998

References

  • Intervention with the aldose reductase inhibitor, tolrestat, in renal and retinal lesions of streptozotocin-diabetic rats
    McCaleb, ML; McKean, ML; Hohman, TC
  • Sorbinil prevents glomerular hyperperfusion in diabetic rats
    Bank, N; Mower, P; Aynedjian, H
  • The effect of aldose reductase inhibitors on glomerular prostaglandin production and urinary albumin excretion in experimental diabetes mellitus
    Chang, WP; Dimitriadis, E; Allen, T
  • Impairment of afferent arteriolar myogenic responsiveness in the galactose-fed rat
    Forster, HG; ter Wee, PM; Takenaka, T
  • Renal renin-angiotensin system in diabetes: Functional immunohistochemical, and molecular biological correlations
    Anderson, S; Jung, FF; Ingelfinger, JR
  • Enhanced renal sensitivity to angiotensin actions in diabetes mellitus in the rat
    Kennefick, TM; Oyama, TT; Thompson, MM
  • Extracellular matrix and its interactions in the diabetic kidney: A molecular biological approach
    Gilbert, RE; Cox, A; Dziadek, M
  • Captopril reduces the risk of nephropathy in IDDM patients with microalbuminuria

You’re reading a free preview. Subscribe to read the entire article.


DeepDyve is your
personal research library

It’s your single place to instantly
discover and read the research
that matters to you.

Enjoy affordable access to
over 18 million articles from more than
15,000 peer-reviewed journals.

All for just $49/month

Explore the DeepDyve Library

Search

Query the DeepDyve database, plus search all of PubMed and Google Scholar seamlessly

Organize

Save any article or search result from DeepDyve, PubMed, and Google Scholar... all in one place.

Access

Get unlimited, online access to over 18 million full-text articles from more than 15,000 scientific journals.

Your journals are on DeepDyve

Read from thousands of the leading scholarly journals from SpringerNature, Elsevier, Wiley-Blackwell, Oxford University Press and more.

All the latest content is available, no embargo periods.

See the journals in your area

DeepDyve

Freelancer

DeepDyve

Pro

Price

FREE

$49/month
$360/year

Save searches from
Google Scholar,
PubMed

Create folders to
organize your research

Export folders, citations

Read DeepDyve articles

Abstract access only

Unlimited access to over
18 million full-text articles

Print

20 pages / month

PDF Discount

20% off