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efficiency. A statistically based parameterization - verification - validation procedure was used to quantify the robustness of the model at simulating rice straw mass, grain yield, and total above ground mass ...
with verification patterns. Each verification pattern served as a filter for rejecting unrealistic parameter sets. The model was then validated by running it with the surviving parameter sets that passed all filters ...
rat n-butanol inhalation exposures that would result in equivalent blood n-butanol concentrations. Consequently, there was a need identified to parameterize and validate a rat model for the inhalation ...
Abstract A panel of experts in physiologically based pharmacokinetic (PBPK) modeling and relevant quantitative methods was convened to describe and discuss model evaluation criteria, issues ...
Abstract The goal of the present study was to assess the predictive performance of a minimal generic rat physiologically based kinetic (PBK) model based on in vitro and in silico input data ...
literature for verification and in order to study its general applicability in human and rat studies. It is noted that due to the natural variation in physiological and kinetic parameters within populations ...
, and expired air. Parameterization . Physiological parameters such as tissue volumes and blood perfusion rates for the various organs were obtained from the literature (Brown et al., 1997). These model parameters ...
for validation . In pattern-oriented modelling (POM), multiple verification patterns are used as filters for rejecting unrealistic model structures and parameter combinations, while a second, independent set ...
. In this work, we are demonstrating the design, verification , and validation of a novel method and system for cuffless, calibration-free evaluation of ΔP from the carotid artery (carotid ΔP). The developed system ...
Abstract The development and application of physiologically based pharmacokinetic (PBPK) models in chemical toxicology have grown steadily since their emergence in the 1980s. However, critical ...
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