Parallel Evaluation of Circulating Tumor DNA and Circulating Tumor Cells in Metastatic Colorectal Cancer

Parallel Evaluation of Circulating Tumor DNA and Circulating Tumor Cells in Metastatic Colorectal... Micro-AbstractLiquid biopsy, encompassing circulating tumor (ctDNA) and circulating tumor cells, is under investigation to overcome spatial and temporal heterogeneity of metastatic colorectal cancer. Limited comparative data are available. In a cohort of 20 patients, we show that ctDNA was detectable in all cases, whereas circulating tumor cells were detectable in one-third of cases. ctDNA analysis appears readily available to be a candidate for clinical application in metastatic colorectal cancer. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Clinical Colorectal Cancer Elsevier

Parallel Evaluation of Circulating Tumor DNA and Circulating Tumor Cells in Metastatic Colorectal Cancer

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Publisher
Elsevier
Copyright
Copyright © 2017 Elsevier Inc.
ISSN
1533-0028
eISSN
1936-0674
D.O.I.
10.1016/j.clcc.2017.10.017
Publisher site
See Article on Publisher Site

Abstract

Micro-AbstractLiquid biopsy, encompassing circulating tumor (ctDNA) and circulating tumor cells, is under investigation to overcome spatial and temporal heterogeneity of metastatic colorectal cancer. Limited comparative data are available. In a cohort of 20 patients, we show that ctDNA was detectable in all cases, whereas circulating tumor cells were detectable in one-third of cases. ctDNA analysis appears readily available to be a candidate for clinical application in metastatic colorectal cancer.

Journal

Clinical Colorectal CancerElsevier

Published: Mar 1, 2018

References

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