Pancreatic α-amylase and lipase inhibitory activity of polyphenolic compounds present in the extract of black chokeberry ( Aronia melanocarpa L.)

Pancreatic α-amylase and lipase inhibitory activity of polyphenolic compounds present in the... 1 Introduction</h5> The number of people suffering from obesity and related health complications is growing rapidly worldwide. WHO has reported that we are dealing with an global obesity epidemic [1] . It is a multifactorial disease that involves genetic and environmental factors. However, one of the major causes of obesity and the disease known as metabolic syndrome is consumption of an excessive amounts of food in relation to the bodily needs. The major problem is the excess of carbohydrates in the diet, especially of simple sugars and those which in the process of digestion are easy to transform; and triacylglycerols, which have the highest energy density (9 kcal/g). As a consequence, there is an abnormal accumulation of body fat [2,3] .</P>Globally, about 35% of adults are overweight and 11% are obese [1] . Therefore, researchers are searching for new treatment opportunities. One of the therapeutic approaches is to reduce the absorption of carbohydrates and lipids in the digestive system. Pancreatic α-amylase (E.C. 3.2.1.1) and lipase (E.C. 3.1.1.3) are the key enzymes in the digestive system, catalyzing the hydrolysis of complex food ingredients such as oligosaccharides and triacylglycerols to simple and easily digestible molecules. The inhibition of these enzymes http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Process Biochemistry Elsevier

Pancreatic α-amylase and lipase inhibitory activity of polyphenolic compounds present in the extract of black chokeberry ( Aronia melanocarpa L.)

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Publisher
Elsevier
Copyright
Copyright © 2014 Elsevier Ltd
ISSN
1359-5113
DOI
10.1016/j.procbio.2014.06.002
Publisher site
See Article on Publisher Site

Abstract

1 Introduction</h5> The number of people suffering from obesity and related health complications is growing rapidly worldwide. WHO has reported that we are dealing with an global obesity epidemic [1] . It is a multifactorial disease that involves genetic and environmental factors. However, one of the major causes of obesity and the disease known as metabolic syndrome is consumption of an excessive amounts of food in relation to the bodily needs. The major problem is the excess of carbohydrates in the diet, especially of simple sugars and those which in the process of digestion are easy to transform; and triacylglycerols, which have the highest energy density (9 kcal/g). As a consequence, there is an abnormal accumulation of body fat [2,3] .</P>Globally, about 35% of adults are overweight and 11% are obese [1] . Therefore, researchers are searching for new treatment opportunities. One of the therapeutic approaches is to reduce the absorption of carbohydrates and lipids in the digestive system. Pancreatic α-amylase (E.C. 3.2.1.1) and lipase (E.C. 3.1.1.3) are the key enzymes in the digestive system, catalyzing the hydrolysis of complex food ingredients such as oligosaccharides and triacylglycerols to simple and easily digestible molecules. The inhibition of these enzymes

Journal

Process BiochemistryElsevier

Published: Sep 1, 2014

References

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    Wang, S.; Moustaid-Moussa, N.; Chen, L.; Mo, H.; Shastri, A.; Su, R.
  • Flavonoids from black chokeberries, Aronia melanocarpa
    Slimestad, R.; Torskangerpoll, K.; Nateland, H.S.; Johannessen, T.; Giske, N.H.
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