Oxytocin Maintains as Well as Initiates Female Sexual Behavior: Effects of a Highly Selective Oxytocin Antagonist

Oxytocin Maintains as Well as Initiates Female Sexual Behavior: Effects of a Highly Selective... In previous studies, central administration of the oxytocin (OT) antagonist d(CH 2 ) 5 (Tyr(Me) 2 , Thr 4 , Tyr-NH 9 2 )OVT (OTA 1 ) blocked receptive and proceptive components of female sexual behavior (FSB) and increased male-directed agonistic behavior when given before progesterone (P) treatment in estradiol-primed female rats but not when given shortly before behavioral testing 4–6 h after P. Because the considerable V 1a antagonist potency of OTA 1 may have contributed to these results, we tested the effects of the far more selective OT antagonist desGly-NH 2 , d(CH 2 ) 5 ( d -Tyr 2 , Thr 4 )OVT (OTA 2 ). In ovariectomized, estradiol benzoate-primed (1 μg × 2 days sc) rats, icv infusion of OTA 2 (1 μg) prior to P injection (250 μg sc) significantly suppressed lordosis and hops and darts and trended toward significantly increasing male-directed kicks during testing at 4 and 6 h. Infusion of OTA 2 3 h and 40 min after P did not alter behavior at 4 and 6 h after P but significantly decreased lordosis as well as hops and darts and increased male-directed kicks 8–12 h after P. These results provide further evidence that central OT receptor activation shortly after P treatment contributes to the subsequent onset and early expression of FSB and demonstrate, for the first time, that OT receptor activation at later time points also contributes to maintaining FSB. The FSB-stimulating effect of central OT appears to persist for several hours. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Hormones and Behavior Elsevier

Oxytocin Maintains as Well as Initiates Female Sexual Behavior: Effects of a Highly Selective Oxytocin Antagonist

Hormones and Behavior, Volume 41 (2) – Mar 1, 2002

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Publisher
Elsevier
Copyright
Copyright © 2002 Elsevier Science (USA)
ISSN
0018-506X
eISSN
1095-6867
D.O.I.
10.1006/hbeh.2001.1736
Publisher site
See Article on Publisher Site

Abstract

In previous studies, central administration of the oxytocin (OT) antagonist d(CH 2 ) 5 (Tyr(Me) 2 , Thr 4 , Tyr-NH 9 2 )OVT (OTA 1 ) blocked receptive and proceptive components of female sexual behavior (FSB) and increased male-directed agonistic behavior when given before progesterone (P) treatment in estradiol-primed female rats but not when given shortly before behavioral testing 4–6 h after P. Because the considerable V 1a antagonist potency of OTA 1 may have contributed to these results, we tested the effects of the far more selective OT antagonist desGly-NH 2 , d(CH 2 ) 5 ( d -Tyr 2 , Thr 4 )OVT (OTA 2 ). In ovariectomized, estradiol benzoate-primed (1 μg × 2 days sc) rats, icv infusion of OTA 2 (1 μg) prior to P injection (250 μg sc) significantly suppressed lordosis and hops and darts and trended toward significantly increasing male-directed kicks during testing at 4 and 6 h. Infusion of OTA 2 3 h and 40 min after P did not alter behavior at 4 and 6 h after P but significantly decreased lordosis as well as hops and darts and increased male-directed kicks 8–12 h after P. These results provide further evidence that central OT receptor activation shortly after P treatment contributes to the subsequent onset and early expression of FSB and demonstrate, for the first time, that OT receptor activation at later time points also contributes to maintaining FSB. The FSB-stimulating effect of central OT appears to persist for several hours.

Journal

Hormones and BehaviorElsevier

Published: Mar 1, 2002

References

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