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kinase C (PKC) δ activation. In the present study, we transfected PKCδ in NB cells resistant to oxidative death induced by L - buthionine - S , R - sulfoximine (BSO), a GSH-depleting agent. Cell responses ...
. , McCulloch , E. A., Minden , M. D., Chow , S ., Curtis , J. ( 1998 ) Antileukemic action of buthionine sulfoximine : evidence for an intrinsic death mechanism based on oxidative stress . Leukemia 12 : 1545 ...
, acetaldehyde, hydrogen peroxide, or L - buthionine - S , R - sulfoximine (BSO) that decreases intracellular glutathione as seen in patients. Then, NS5A region was sequenced and compared with genotype 1b HCV sequences ...
induced by either hydrogen peroxide (H2O2), or a glutathione depletor, L ‐ buthionine ‐[ S , R ]‐ sulfoximine (BSO). This protective effect was reversed by coadministration with the cGMP‐dependent protein kinase ...
along with the increase in HO‐1 mRNA level. The increase in transcription of HO‐1 was a direct response to GSH depletion, as judged by the observation that treatment of neonatal rats with L ‐ buthionine ‐( S ...
effect, reducing malondialdehyde formation in cells treated with l ‐ buthionine ‐( S , R )‐ sulfoximine , a glutathione depletor and, interestingly, the effect of PEA was partially inhibited by finasteride, a 5α ...
. In this study, the effect of PO on oxidative stress induced by inhibition of GSH synthesis (using buthionine sulfoximine [BSO]) was examined. Methods: Sprague-Dawley rats were separated into two groups ...
/kg/day) on oxidative stress , induced by glutathione (GSH) depletion (using buthionine - sulfoximine , BSO, 30 mmol/ L /day in the drinking water), in Sprague-Dawley rats. Methods: Mean arterial pressure ...
phase). The acute phase of lindane- induced inhibition of dye transfer was prevented by GSH depletion with L - buthionine -[ S , R ]- sulfoximine (BSO) and enhanced by GSH augmentation with GSH monoethyl ester ...
hepatocytes treated with high concentrations of VPA. MATERIALS AND METHODS Chemicals. 2-Propyl pentanoic acid (sodium valproate, VPA), DL- buthionine -[ S , R ]- sulfoximine (BSO), diethylmaleate (DEM), butylated ...
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