Advanced Drug Delivery Reviews 126 (2018) 96–112 Contents lists available at ScienceDirect Advanced Drug Delivery Reviews journal homepage: www.elsevier.com/locate/addr Overcoming ocular drug delivery barriers through the use of physical forces Di Huang, Ying-Shan Chen, Ilva D. Rupenthal Buchanan Ocular Therapeutics Unit, Department of Ophthalmology, New Zealand National Eye Centre, Faculty of Medical and Health Sciences, The University of Auckland, Private Bag 92019, Auckland 1142, New Zealand article i nfo abstract Article history: Overcoming the physiological barriers in the eye remains a key obstacle in the ﬁeld of ocular drug delivery. While Received 23 November 2016 ocular barriers naturally have a protective function, they also limit drug entry into the eye. Various pharmaceu- Received in revised form 30 June 2017 tical strategies, such as novel formulations and physical force-based techniques, have been investigated to weak- Accepted 8 September 2017 en these barriers and transport therapeutic agents effectively to both the anterior and the posterior segments of Available online 12 September 2017 the eye. This review summarizes and discusses the recent research progress in the ﬁeld of ocular drug delivery with a focus on the application of physical methods, including electrical ﬁelds, sonophoresis, and microneedles, Keywords: which can enhance penetration efﬁciency
It’s your single place to instantly
discover and read the research
that matters to you.
Enjoy affordable access to
over 18 million articles from more than
15,000 peer-reviewed journals.
All for just $49/month
Query the DeepDyve database, plus search all of PubMed and Google Scholar seamlessly
Save any article or search result from DeepDyve, PubMed, and Google Scholar... all in one place.
Get unlimited, online access to over 18 million full-text articles from more than 15,000 scientific journals.
Read from thousands of the leading scholarly journals from SpringerNature, Wiley-Blackwell, Oxford University Press and more.
All the latest content is available, no embargo periods.
“Hi guys, I cannot tell you how much I love this resource. Incredible. I really believe you've hit the nail on the head with this site in regards to solving the research-purchase issue.”Daniel C.
“Whoa! It’s like Spotify but for academic articles.”@Phil_Robichaud
“I must say, @deepdyve is a fabulous solution to the independent researcher's problem of #access to #information.”@deepthiw
“My last article couldn't be possible without the platform @deepdyve that makes journal papers cheaper.”@JoseServera