10.1016/j.addr.2017.09.008

10.1016/j.addr.2017.09.008 Advanced Drug Delivery Reviews 126 (2018) 96–112 Contents lists available at ScienceDirect Advanced Drug Delivery Reviews journal homepage: www.elsevier.com/locate/addr Overcoming ocular drug delivery barriers through the use of physical forces Di Huang, Ying-Shan Chen, Ilva D. Rupenthal Buchanan Ocular Therapeutics Unit, Department of Ophthalmology, New Zealand National Eye Centre, Faculty of Medical and Health Sciences, The University of Auckland, Private Bag 92019, Auckland 1142, New Zealand article i nfo abstract Article history: Overcoming the physiological barriers in the eye remains a key obstacle in the field of ocular drug delivery. While Received 23 November 2016 ocular barriers naturally have a protective function, they also limit drug entry into the eye. Various pharmaceu- Received in revised form 30 June 2017 tical strategies, such as novel formulations and physical force-based techniques, have been investigated to weak- Accepted 8 September 2017 en these barriers and transport therapeutic agents effectively to both the anterior and the posterior segments of Available online 12 September 2017 the eye. This review summarizes and discusses the recent research progress in the field of ocular drug delivery with a focus on the application of physical methods, including electrical fields, sonophoresis, and microneedles, Keywords: which can enhance penetration efficiency http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png

10.1016/j.addr.2017.09.008

Elsevier — Jun 11, 2020

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Abstract

Advanced Drug Delivery Reviews 126 (2018) 96–112 Contents lists available at ScienceDirect Advanced Drug Delivery Reviews journal homepage: www.elsevier.com/locate/addr Overcoming ocular drug delivery barriers through the use of physical forces Di Huang, Ying-Shan Chen, Ilva D. Rupenthal Buchanan Ocular Therapeutics Unit, Department of Ophthalmology, New Zealand National Eye Centre, Faculty of Medical and Health Sciences, The University of Auckland, Private Bag 92019, Auckland 1142, New Zealand article i nfo abstract Article history: Overcoming the physiological barriers in the eye remains a key obstacle in the field of ocular drug delivery. While Received 23 November 2016 ocular barriers naturally have a protective function, they also limit drug entry into the eye. Various pharmaceu- Received in revised form 30 June 2017 tical strategies, such as novel formulations and physical force-based techniques, have been investigated to weak- Accepted 8 September 2017 en these barriers and transport therapeutic agents effectively to both the anterior and the posterior segments of Available online 12 September 2017 the eye. This review summarizes and discusses the recent research progress in the field of ocular drug delivery with a focus on the application of physical methods, including electrical fields, sonophoresis, and microneedles, Keywords: which can enhance penetration efficiency

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