Otx2 , Gbx2 and Fgf8 interact to position and maintain a mid–hindbrain organizer

Otx2 , Gbx2 and Fgf8 interact to position and maintain a mid–hindbrain organizer A decade ago, chick–quail transplantation studies demonstrated that the junction between the midbrain and hindbrain has the properties of an organizing center capable of patterning the midbrain and cerebellum. Many of the genes that function to pattern these tissues have been identified and extensively studied. Recent experiments have shown that Otx2 , Gbx2 and Fgf8 genes play a major role in the positioning and functioning of this organizing center. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Current Opinion in Cell Biology Elsevier

Otx2 , Gbx2 and Fgf8 interact to position and maintain a mid–hindbrain organizer

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Publisher
Elsevier
Copyright
Copyright © 2000 Elsevier Science Ltd
ISSN
0955-0674
DOI
10.1016/S0955-0674(00)00161-7
Publisher site
See Article on Publisher Site

Abstract

A decade ago, chick–quail transplantation studies demonstrated that the junction between the midbrain and hindbrain has the properties of an organizing center capable of patterning the midbrain and cerebellum. Many of the genes that function to pattern these tissues have been identified and extensively studied. Recent experiments have shown that Otx2 , Gbx2 and Fgf8 genes play a major role in the positioning and functioning of this organizing center.

Journal

Current Opinion in Cell BiologyElsevier

Published: Dec 1, 2000

References

  • Otx1 and Otx2 in the development and evolution of the mammalian brain
    Simeone, A

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