Otx Genes and the Genetic Control of Brain Morphogenesis

Otx Genes and the Genetic Control of Brain Morphogenesis Understanding the genetic mechanisms that control brain patterning in vertebrates represents a major challenge for developmental neurobiology. The cloning of genes likely to be involved in the organization of the brain and an analysis of their roles have revealed insights into the molecular pathways leading to neural induction, tissue specification, and regionalization of the brain. Among these genes, both Otx1 and Otx2, two murine homologs of the Drosophila orthodenticle ( otd ) gene, contribute to several steps in brain morphogenesis. Recent findings have demonstrated that Otx2 plays a major role in gastrulation and in the early specification of the anterior neural plate while Otx1 is mainly involved in corticogenesis, and Otx1 and Otx2 genes cooperate in such a way that a minimal level of OTX proteins are required for proper regionalization and subsequent patterning of the developing brain. Finally, experiments have shown functional equivalence between Drosophila otd and vertebrate Otx genes, suggesting a surprising conservation of function required in brain development throughout evolution. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Molecular and Cellular Neuroscience Elsevier

Otx Genes and the Genetic Control of Brain Morphogenesis

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Publisher
Elsevier
Copyright
Copyright © 1999 Academic Press
ISSN
1044-7431
DOI
10.1006/mcne.1998.0730
Publisher site
See Article on Publisher Site

Abstract

Understanding the genetic mechanisms that control brain patterning in vertebrates represents a major challenge for developmental neurobiology. The cloning of genes likely to be involved in the organization of the brain and an analysis of their roles have revealed insights into the molecular pathways leading to neural induction, tissue specification, and regionalization of the brain. Among these genes, both Otx1 and Otx2, two murine homologs of the Drosophila orthodenticle ( otd ) gene, contribute to several steps in brain morphogenesis. Recent findings have demonstrated that Otx2 plays a major role in gastrulation and in the early specification of the anterior neural plate while Otx1 is mainly involved in corticogenesis, and Otx1 and Otx2 genes cooperate in such a way that a minimal level of OTX proteins are required for proper regionalization and subsequent patterning of the developing brain. Finally, experiments have shown functional equivalence between Drosophila otd and vertebrate Otx genes, suggesting a surprising conservation of function required in brain development throughout evolution.

Journal

Molecular and Cellular NeuroscienceElsevier

Published: Jan 1, 1999

References

  • Retinoic acid induces stage-specific repatterning of the rostral central nervous system
    Avantaggiato, V.; Acampora, D.; Tuorto, F.; Simeone, A.
  • Determination events in the nervous system of the vertebrate embryo
    Bally-Cuif, L.; Wassef, M.
  • Mediation of Drosophila
    Cohen, S.M.; Jürgens, G.
  • The orthodenticle Drosophila
    Finkelstein, R.; Smouse, D.; Capaci, T.M.; Spradling, A.C.; Perrimon, N.
  • Patterning the embryonic forebrain
    Rubenstein, J.L.R.; Beachy, P.A.
  • Regionalization of the prosencephalic neural plate
    Rubenstein, J.L.R.; Shimamura, K.; Martinez, S.; Puelles, L.
  • Anterior primitive endoderm may be responsible for patterning the anterior neural plate in the mouse embryo
    Thomas, P.; Beddington, R.
  • Control of early neurogenesis of the Drosophila tll, otd, ems btd
    Younossi-Hartenstein, A.; Green, P.; Liaw, G.J.; Rudolph, K.; Lengyel, J.; Hartenstein, V.

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