Optic nerve blood-flow abnormalities in glaucoma

Optic nerve blood-flow abnormalities in glaucoma Glaucoma can be defined as an optic nerve disease with typical morphological and functional changes. There are many risk factors associated with this neuropathy. The best known factor is an increased intraocular pressure. There are, however, many other risk factors. Among them, vascular factors play a major role. Although such vascular factors have been postulated more than hundred years ago, it is only recently that the physiology and pathophysiology of the optic nerve head circulation is, to some extent, understood. New instruments have been developed to measure ocular blood flow including blood flow in the optic nerve head. Although most of the studies indicate that circulation is changed in glaucoma patients, there is little association between glaucoma and arteriosclerosis. The main cause for the circulation disturbance in glaucoma seems rather to be a vascular dysregulation leading to local vasospasm and to systemic hypotension. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Progress in Retinal and Eye Research Elsevier

Optic nerve blood-flow abnormalities in glaucoma

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Publisher
Elsevier
Copyright
Copyright © 1997 Elsevier Science Ltd
ISSN
1350-9462
eISSN
1873-1635
D.O.I.
10.1016/S1350-9462(97)00006-2
Publisher site
See Article on Publisher Site

Abstract

Glaucoma can be defined as an optic nerve disease with typical morphological and functional changes. There are many risk factors associated with this neuropathy. The best known factor is an increased intraocular pressure. There are, however, many other risk factors. Among them, vascular factors play a major role. Although such vascular factors have been postulated more than hundred years ago, it is only recently that the physiology and pathophysiology of the optic nerve head circulation is, to some extent, understood. New instruments have been developed to measure ocular blood flow including blood flow in the optic nerve head. Although most of the studies indicate that circulation is changed in glaucoma patients, there is little association between glaucoma and arteriosclerosis. The main cause for the circulation disturbance in glaucoma seems rather to be a vascular dysregulation leading to local vasospasm and to systemic hypotension.

Journal

Progress in Retinal and Eye ResearchElsevier

Published: Apr 1, 1998

References

  • Autoregulation of blood flow
    Johnson, P.C.
  • Systemic blood pressure in glaucoma patients
    Kaiser, H.J.; Flammer, J.; Graf, T.; Stümpfig, D.
  • Role of tissue hypoxia in local regulation of cerebral microcirculation
    Kontos, H.A.; Wei, E.P.; Raper, A.J.; Rosenblum, W.I.; Navari, R.M.; Patterson, J.L.
  • Regulation of regional cerebral blood flow during and between migraine attacks
    Lauritzen, M.; Olsen, T.S.; Lassen, N.A.; Paulson, O.B.
  • Renin–angiotensin: biochemistry and mechanisms of action
    Peach, M.J.
  • Effects of oxygen on blood flow autoregulation in cat sartorius muscle
    Sullivan, S.M.; Johnson, P.C.

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