Oleanolic acid protects against cognitive decline and neuroinflammation-mediated neurotoxicity by blocking secretory phospholipase A2 IIA-activated calcium signals

Oleanolic acid protects against cognitive decline and neuroinflammation-mediated neurotoxicity by... •Oleanolic acid suppresses inflammatory response in Aβ-activated astrocyte.•OA attenuates Aβ-stimulated astrocytes-induced neuronal growth inhibition.•OA restrains Aβ-induced expression and release of sPLA2-IIA.•OA protects against Aβ-induced neurotoxicity by blocking sPLA2-IIA-evoked Ca2+ influx.•OA ameliorates cognitive deficits and inflammatory response in AD rats. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Molecular Immunology Elsevier

Oleanolic acid protects against cognitive decline and neuroinflammation-mediated neurotoxicity by blocking secretory phospholipase A2 IIA-activated calcium signals

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Publisher
Elsevier
Copyright
Copyright © 2018 Elsevier Ltd
ISSN
0161-5890
D.O.I.
10.1016/j.molimm.2018.04.015
Publisher site
See Article on Publisher Site

Abstract

•Oleanolic acid suppresses inflammatory response in Aβ-activated astrocyte.•OA attenuates Aβ-stimulated astrocytes-induced neuronal growth inhibition.•OA restrains Aβ-induced expression and release of sPLA2-IIA.•OA protects against Aβ-induced neurotoxicity by blocking sPLA2-IIA-evoked Ca2+ influx.•OA ameliorates cognitive deficits and inflammatory response in AD rats.

Journal

Molecular ImmunologyElsevier

Published: Jul 1, 2018

References

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