Oleamide and anandamide effects on food intake and sexual behavior of rats

Oleamide and anandamide effects on food intake and sexual behavior of rats Oleamide is a lipid with diverse properties, including cannabinoid-like activity. For example, it induces the classic triad of effects attributable to these molecules: decrease in core temperature, hypolocomotion, and reduction in pain perception. However, as it binds to the cannabinoid receptors (CB1) only at high concentrations, it is not considered an actual endocannabinoid. In this study, we tested the effect of oleamide on food intake and sexual behavior and compared it to the effect induced by anandamide. Results indicate that oleamide and anandamide increased food intake during the 3 h post-injection. In addition, anandamide but not oleamide induced changes in sexual performance. This study further supports the role of endocannabinoids in food ingestion and male sexual behavior and gives additional support to the notion that, although oleamide might not be an endocannabinoid, it shares some effects with them. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Neuroscience Letters Elsevier

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Publisher
Elsevier
Copyright
Copyright © 2004 Elsevier Ireland Ltd
ISSN
0304-3940
D.O.I.
10.1016/j.neulet.2004.03.080
Publisher site
See Article on Publisher Site

Abstract

Oleamide is a lipid with diverse properties, including cannabinoid-like activity. For example, it induces the classic triad of effects attributable to these molecules: decrease in core temperature, hypolocomotion, and reduction in pain perception. However, as it binds to the cannabinoid receptors (CB1) only at high concentrations, it is not considered an actual endocannabinoid. In this study, we tested the effect of oleamide on food intake and sexual behavior and compared it to the effect induced by anandamide. Results indicate that oleamide and anandamide increased food intake during the 3 h post-injection. In addition, anandamide but not oleamide induced changes in sexual performance. This study further supports the role of endocannabinoids in food ingestion and male sexual behavior and gives additional support to the notion that, although oleamide might not be an endocannabinoid, it shares some effects with them.

Journal

Neuroscience LettersElsevier

Published: Jun 24, 2004

References

  • The effects of cannabinoids on the brain
    Ameri, A
  • Low dose anandamide affects food intake, cognitive function, neurotransmitter and corticosterone levels in diet-restricted mice
    Hao, S; Avraham, Y; Mechoulam, R; Berry, E.M
  • Anandamide administration into the ventromedial hypothalamus stimulates appetite in rats
    Jamshidi, N; Taylor, D.A
  • Oleamide modulates memory in rats
    Murillo-Rodrı́guez, E; Giordano, M; Cabeza, R; Henriksen, S.J; Méndez-Dı́az, M; Navarro, L; Prospéro-Garcı́a, O
  • Anandamide induces overeating: mediation by central cannabinoid (CB1) receptors
    Williams, C.M; Kirkham, T.C

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