Occurrence of drugs in German sewage treatment plants and rivers 1 Dedicated to Professor Dr. Klaus Haberer on the occasion of his 70th birthday. 1

Occurrence of drugs in German sewage treatment plants and rivers 1 Dedicated to Professor Dr.... The occurrence of 32 drug residues belonging to different medicinal classes like antiphlogistics, lipid regulators, psychiatric drugs, antiepileptic drugs, betablockers and β 2 -sympathomimetics as well as five metabolites has been investigated in German municipal sewage treatment plant (STP) discharges, river and stream waters. Due to the incomplete removal of drug residues during passage through a STP, above 80% of the selected drugs were detectable in at least one municipal STP effluent with concentration levels up to 6.3 μ g l −1 (carbamazepine) and thus resulting in the contamination of the receiving waters. 20 different drugs and 4 corresponding metabolites were measured in river and stream waters. Mainly acidic drugs like the lipid regulators bezafibrate, gemfibrozil, the antiphlogistics diclofenac, ibuprofen, indometacine, naproxen, phenazone and the metabolites clofibric acid, fenofibric acid and salicylic acid as well as neutral or weak basic drugs like the betablockers metoprolol, propranolol and the antiepileptic drug carbamazepine were found to be ubiquitously present in the riversand streams, mostly in the ng l −1 -range. However, maximum concentrations were determined up to 3.1 μ g l −1 and median values as high as 0.35 μ g l −1 (both bezafibrate). The drugs detected in the environment were predominantly applied in human medicine. It can therefore be assumed that the load of municipal STP effluents in the surface water highly influences the contamination. Due to their wide-spread presence in the aquatic environment many of these drugs have to be classified as relevant environmental chemicals. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Water Research Elsevier

Occurrence of drugs in German sewage treatment plants and rivers 1 Dedicated to Professor Dr. Klaus Haberer on the occasion of his 70th birthday. 1

Water Research, Volume 32 (11) – Nov 1, 1998

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Publisher
Elsevier
Copyright
Copyright © 1998 Elsevier Science Ltd
ISSN
0043-1354
D.O.I.
10.1016/S0043-1354(98)00099-2
Publisher site
See Article on Publisher Site

Abstract

The occurrence of 32 drug residues belonging to different medicinal classes like antiphlogistics, lipid regulators, psychiatric drugs, antiepileptic drugs, betablockers and β 2 -sympathomimetics as well as five metabolites has been investigated in German municipal sewage treatment plant (STP) discharges, river and stream waters. Due to the incomplete removal of drug residues during passage through a STP, above 80% of the selected drugs were detectable in at least one municipal STP effluent with concentration levels up to 6.3 μ g l −1 (carbamazepine) and thus resulting in the contamination of the receiving waters. 20 different drugs and 4 corresponding metabolites were measured in river and stream waters. Mainly acidic drugs like the lipid regulators bezafibrate, gemfibrozil, the antiphlogistics diclofenac, ibuprofen, indometacine, naproxen, phenazone and the metabolites clofibric acid, fenofibric acid and salicylic acid as well as neutral or weak basic drugs like the betablockers metoprolol, propranolol and the antiepileptic drug carbamazepine were found to be ubiquitously present in the riversand streams, mostly in the ng l −1 -range. However, maximum concentrations were determined up to 3.1 μ g l −1 and median values as high as 0.35 μ g l −1 (both bezafibrate). The drugs detected in the environment were predominantly applied in human medicine. It can therefore be assumed that the load of municipal STP effluents in the surface water highly influences the contamination. Due to their wide-spread presence in the aquatic environment many of these drugs have to be classified as relevant environmental chemicals.

Journal

Water ResearchElsevier

Published: Nov 1, 1998

References

  • Disposition pharmacokinetics of bezafibrate in man
    Abshagen, U; Bablok, W; Koch, K; Schmidt, H.A.E; Senn, M; Stork, H
  • The relevance of the presence of certain synthetic steroids in the aquatic environment
    Aherne, G.W; Briggs, R
  • The fate of pharmaceutical chemicals in the aquatic environment
    Richardson, M.L; Bowron, J.M

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