10.1016/j.ejmech.2017.11.075

10.1016/j.ejmech.2017.11.075 European Journal of Medicinal Chemistry 143 (2018) 306e319 Contents lists available at ScienceDirect European Journal of Medicinal Chemistry journal homepage: http://www.elsevier.com/locate/ejmech Research paper a a a a a, 1 Muthusamy Venkatraj , Irene G. Salado , Jan Heeres , Jurgen Joossens , Paul J. Lewi , b b a a, * Guy Caljon , Louis Maes , Pieter Van der Veken , Koen Augustyns Laboratory of Medicinal Chemistry, University of Antwerp, Universiteitsplein 1, B-2610 Antwerp, Belgium Laboratory for Microbiology, Parasitology and Hygiene (LMPH), University of Antwerp, Universiteitsplein 1, B-2610 Antwerp, Belgium article i nf o abstract Article history: Human African trypanosomiasis (HAT), also known as sleeping sickness is a parasitic disease transmitted Received 27 October 2017 by the bite of the 'Glossina' insect, commonly known as the tsetse fly. This disease affects mostly poor Accepted 26 November 2017 populations living in remote rural areas of Africa. Untreated, it is usually fatal. Currently, safe and Available online 27 November 2017 effective treatments against this disease are lacking. Phenotypic screening of triazine non-nucleoside HIV-1 reverse transcriptase inhibitors (monomers) resulted in potent and selective antitrypanosomal Keywords: compounds. This serendipitous discovery and the presence of dimers in many compounds active against Trypanosoma brucei http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png

10.1016/j.ejmech.2017.11.075

Elsevier — Jun 11, 2020

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Elsevier

Abstract

European Journal of Medicinal Chemistry 143 (2018) 306e319 Contents lists available at ScienceDirect European Journal of Medicinal Chemistry journal homepage: http://www.elsevier.com/locate/ejmech Research paper a a a a a, 1 Muthusamy Venkatraj , Irene G. Salado , Jan Heeres , Jurgen Joossens , Paul J. Lewi , b b a a, * Guy Caljon , Louis Maes , Pieter Van der Veken , Koen Augustyns Laboratory of Medicinal Chemistry, University of Antwerp, Universiteitsplein 1, B-2610 Antwerp, Belgium Laboratory for Microbiology, Parasitology and Hygiene (LMPH), University of Antwerp, Universiteitsplein 1, B-2610 Antwerp, Belgium article i nf o abstract Article history: Human African trypanosomiasis (HAT), also known as sleeping sickness is a parasitic disease transmitted Received 27 October 2017 by the bite of the 'Glossina' insect, commonly known as the tsetse fly. This disease affects mostly poor Accepted 26 November 2017 populations living in remote rural areas of Africa. Untreated, it is usually fatal. Currently, safe and Available online 27 November 2017 effective treatments against this disease are lacking. Phenotypic screening of triazine non-nucleoside HIV-1 reverse transcriptase inhibitors (monomers) resulted in potent and selective antitrypanosomal Keywords: compounds. This serendipitous discovery and the presence of dimers in many compounds active against Trypanosoma brucei

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