Novel superparamagnetic iron oxide nanoparticles for tumor embolization application: Preparation, characterization and double targeting

Novel superparamagnetic iron oxide nanoparticles for tumor embolization application: Preparation,... Article history: The goal of this study was to develop novel embolic nanoparticles for targeted tumor therapy with dual Received 4 November 2011 targeting: magnetic field-guided and peptide-directed targeting. The embolic nanoparticles SP5.2/tTF- Received in revised form 14 January 2012 OCMCs-SPIO-NPs were prepared by surface-modifying of superparamagnetic iron oxide nanoparticles Accepted 19 January 2012 (SPIO-NPs) with o-carboxymethylchitosans (OCMCs) and SP5.2/tTF (SP5.2: a peptide binding to VEGFR- Available online 30 January 2012 1; tTF: truncated tissue factor) to improve their stability and to target over-expressing VEGFR-1 cells. The physicochemical characterization results showed that the OCMCs-SPIO-NPs have a spherical or Keywords: ellipsoidal morphology with an average diameter of 10–20 nm. And they possess magnetism with a Magnetic nanoparticles saturation magnetization of 66.1 emu/g, negligible coercivity and remanence at room temperature. In Superparamagnetic addition, the confocal microscopy, Prussian blue staining and FX activation analysis respectively demon- o-Carboxymethylchitosan strated the peptide-directed targeting, magnetic field-guided targeted and blood coagulation activity of Truncated tissue factor Tumor targeting the SP5.2/tTF-OCMCs-SPIO-NPs. These properties separately belong to SP5.2, Fe O and tTF moieties of 3 4 the SP5.2/tTF-OCMCs-SPIO-NPs. Thus these SP5.2/tTF-OCMCs-SPIO-NPs with double-targeting function should have a potential application in embolization therapy of tumor blood vessels. © 2012 http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png International Journal of Pharmaceutics Elsevier

Novel superparamagnetic iron oxide nanoparticles for tumor embolization application: Preparation, characterization and double targeting

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Publisher
Elsevier
Copyright
Copyright © 2012 Elsevier B.V.
ISSN
0378-5173
D.O.I.
10.1016/j.ijpharm.2012.01.043
Publisher site
See Article on Publisher Site

Abstract

Article history: The goal of this study was to develop novel embolic nanoparticles for targeted tumor therapy with dual Received 4 November 2011 targeting: magnetic field-guided and peptide-directed targeting. The embolic nanoparticles SP5.2/tTF- Received in revised form 14 January 2012 OCMCs-SPIO-NPs were prepared by surface-modifying of superparamagnetic iron oxide nanoparticles Accepted 19 January 2012 (SPIO-NPs) with o-carboxymethylchitosans (OCMCs) and SP5.2/tTF (SP5.2: a peptide binding to VEGFR- Available online 30 January 2012 1; tTF: truncated tissue factor) to improve their stability and to target over-expressing VEGFR-1 cells. The physicochemical characterization results showed that the OCMCs-SPIO-NPs have a spherical or Keywords: ellipsoidal morphology with an average diameter of 10–20 nm. And they possess magnetism with a Magnetic nanoparticles saturation magnetization of 66.1 emu/g, negligible coercivity and remanence at room temperature. In Superparamagnetic addition, the confocal microscopy, Prussian blue staining and FX activation analysis respectively demon- o-Carboxymethylchitosan strated the peptide-directed targeting, magnetic field-guided targeted and blood coagulation activity of Truncated tissue factor Tumor targeting the SP5.2/tTF-OCMCs-SPIO-NPs. These properties separately belong to SP5.2, Fe O and tTF moieties of 3 4 the SP5.2/tTF-OCMCs-SPIO-NPs. Thus these SP5.2/tTF-OCMCs-SPIO-NPs with double-targeting function should have a potential application in embolization therapy of tumor blood vessels. © 2012

Journal

International Journal of PharmaceuticsElsevier

Published: Apr 15, 2012

References

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