Novel antagonist implicates the CB 1 cannabinoid receptor in the hypotensive action of anandamide

Novel antagonist implicates the CB 1 cannabinoid receptor in the hypotensive action of anandamide In anaesthetised rats, the endogenous cannabinoid anandamide has potent cardiovascular effects that include a brief pressor effect and a more prolonged depressor response. The depressor response is attenuated after transection of the cervical spinal cord or blockade of α-adrenergic receptors by phentolamine, and is dose-dependently inhibited by a selective antagonist of the CB 1 cannabinoid receptor. The pressor component is not affected by any of these interventions. This suggests that the depressor response is due to inhibition of sympathetic tone mediated by CB 1 receptors, whereas the pressor component is due to a peripheral action that does not involve the same receptors or the sympathetic nervous system. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png European Journal of Pharmacology Elsevier

Novel antagonist implicates the CB 1 cannabinoid receptor in the hypotensive action of anandamide

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Publisher
Elsevier
Copyright
Copyright © 1995 Elsevier Ltd
ISSN
0014-2999
DOI
10.1016/0014-2999(95)00181-J
Publisher site
See Article on Publisher Site

Abstract

In anaesthetised rats, the endogenous cannabinoid anandamide has potent cardiovascular effects that include a brief pressor effect and a more prolonged depressor response. The depressor response is attenuated after transection of the cervical spinal cord or blockade of α-adrenergic receptors by phentolamine, and is dose-dependently inhibited by a selective antagonist of the CB 1 cannabinoid receptor. The pressor component is not affected by any of these interventions. This suggests that the depressor response is due to inhibition of sympathetic tone mediated by CB 1 receptors, whereas the pressor component is due to a peripheral action that does not involve the same receptors or the sympathetic nervous system.

Journal

European Journal of PharmacologyElsevier

Published: May 24, 1995

References

  • Effect of anesthetic on sympathetic responses evoked from cerebellar uvula in decerebrate cats
    Paton, J.F.; Gilbey, M.P.

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