“Whoa! It’s like Spotify but for academic articles.”

Instant Access to Thousands of Journals for just $40/month

Try 2 weeks free now

Novel 2-methoxyacylhydrazones as potent, selective PDE10A inhibitors with activity in animal models of schizophrenia

Schizophrenia is a debilitating disease affecting approximately 1% of the world population. 1 Current pharmaceutical agents used to treat schizophrenia include the typical antipsychotics that effectively address positive symptoms such as hallucinations and delusions. These drugs exert their effect through action as D2 receptor antagonists. However, some drawbacks of these medications are motor side effects and lack of efficacy in a subset of the patient population. 2 Contemporary ‘atypical’ antipsychotics possessing mixed D2/5HT2A antagonism have reduced severity of motor side effects, but can cause deleterious metabolic consequences. Besides the need for new antipsychotic agents without unwanted side effects, pharmaceuticals are needed that address cognitive symptoms which include impairment of working memory and executive function as well as negative symptoms such as social withdrawal. The severity of the cognitive effects of schizophrenia has been shown to be a predominant determinant in the overall prognosis of patient function. Thus, pharmaceutical entities for schizophrenia are needed that can manage both positive and negative symptoms along with cognitive deficits. Phosphodiesterase 10A (PDE10A) is a dual-specificity phosphodiesterase that hydrolyzes both cyclic adenosine and cyclic guanosine monophosphate (cAMP and cGMP). 3a It is expressed predominantly in brain, with highest concentrations in the medium spiny http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Bioorganic & Medicinal Chemistry Letters Elsevier
Loading next page...

You’re reading a free preview. Subscribe to read the entire article.

DeepDyve is your
personal research library

It’s your single place to instantly
discover and read the research
that matters to you.

Enjoy unlimited access and
personalized recommendations from
over 12 million articles from more than
10,000 peer-reviewed journals.

All for just $40/month

Try 2 weeks free now

Explore the DeepDyve Library

How DeepDyve Works

Spend time researching, not time worrying you’re buying articles that might not be useful.

Unlimited reading

Read as many articles as you need. Full articles with original layout, charts and figures. Read online, from anywhere.

Stay up to date

Keep up with your field with Personalized Recommendations and Follow Journals to get automatic updates.

Organize your research

It’s easy to organize your research with our built-in tools.

Your journals are on DeepDyve

Read from thousands of the leading scholarly journals from Springer, Elsevier, Nature, IEEE, Wiley-Blackwell and more.

All the latest content is available, no embargo periods.

See the journals in your area

Simple and Affordable Pricing

14-day free trial. Cancel anytime, with a 30-day money-back guarantee.

Monthly Plan

  • Read unlimited articles
  • Personalized recommendations
  • Print 20 pages per month
  • 20% off on PDF purchases
  • Organize your research
  • Get updates on your journals and topic searches


Best Deal — 25% off

Annual Plan

  • All the features of the Professional Plan, but for 25% off!
  • For the normal price of 10 articles elsewhere, you get one full year of unlimited access to articles.

billed annually