Molecular Immunology 99 (2018) 191–198 Contents lists available at ScienceDirect Molecular Immunology journal homepage: www.elsevier.com/locate/molimm Notch1 primes CD4 T cells for T helper type I diﬀerentiation through its early eﬀects on miR-29 a,1 b c b,2 Karthik Chandiran , Rebecca Lawlor , Antonio Pannuti , Gabriela Gonzalez Perez , b,d e c a,b a,b, Janani Srinivasan , Todd E. Golde , Lucio Miele , Barbara A. Osborne , Lisa M. Minter Graduate Program in Molecular and Cellular Biology, University of Massachusetts Amherst, Amherst, MA, 01003, United States Department of Veterinary and Animal Sciences, University of Massachusetts Amherst, Amherst, MA, 01003, United States Department of Genetics and Stanley S. Scott Cancer Center, Louisiana State University Health Sciences Center, New Orleans, LA, 70112, United States Department of Biomedical Sciences, University of Illinois, Rockford College of Medicine, Rockford, IL, 61107, United States Department of Neuroscience, Center for Translational Research in Neurodegenerative Disease, and McKnight Brain Institute, College of Medicine, University of Florida, Gainesville, FL, 32610, United States ARTIC L E I NF O ABSTRAC T Keywords: The transmembrane receptor, Notch1 plays an important role during the diﬀerentiation of CD4 T cells into T Notch1 helper (Th) subsets in the presence of appropriate
Molecular Immunology – Elsevier
Published: Jul 1, 2018
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