1 Introduction</h5> Mast cells are thought to play a pivotal role in allergy and other inflammatory diseases. While IgE is thought to have a central role in mast cell activation by cross-linking of the high affinity FcεRI ( Okayama et al., 2008 ), also non-IgE mediated mast cell activation may be of importance in the pathophysiology of various inflammatory conditions.</P>Mast cells are located in close contact with external environment, where they can recognize and be activated by invasive pathogens through complement- and pattern recognition receptor (PRR)-dependent pathways ( Marshall, 2004 ). They are also located close to sensory nerve endings, where they are triggered by a pleotropic variety of neuropeptides, such as substance P, corticotrophin-releasing hormone (CRH) and neurotrophins, suggesting that mast cells are involved in neuro-inflammatory diseases ( Kulka et al., 2008 ). Moreover, mast cells can respond to various inflammatory products, such as IgG, cytokines, chemokines, adenosine, sphingosine-1-phosphate (S1P) and lysophosphatidic acid (LPA), indicating the potential importance of mast cell activation in the initiation and propagation of inflammation in chronic inflammatory diseases. Apart from these endogenous stimuli, some exogenous molecules can also directly activate mast cells, causing drug side-effects or exacerbating allergic conditions in individuals. In
European Journal of Pharmacology – Elsevier
Published: May 5, 2016
It’s your single place to instantly
discover and read the research
that matters to you.
Enjoy affordable access to
over 18 million articles from more than
15,000 peer-reviewed journals.
All for just $49/month
Query the DeepDyve database, plus search all of PubMed and Google Scholar seamlessly
Save any article or search result from DeepDyve, PubMed, and Google Scholar... all in one place.
Get unlimited, online access to over 18 million full-text articles from more than 15,000 scientific journals.
Read from thousands of the leading scholarly journals from SpringerNature, Elsevier, Wiley-Blackwell, Oxford University Press and more.
All the latest content is available, no embargo periods.
“Hi guys, I cannot tell you how much I love this resource. Incredible. I really believe you've hit the nail on the head with this site in regards to solving the research-purchase issue.”
Daniel C.
“Whoa! It’s like Spotify but for academic articles.”
@Phil_Robichaud
“I must say, @deepdyve is a fabulous solution to the independent researcher's problem of #access to #information.”
@deepthiw
“My last article couldn't be possible without the platform @deepdyve that makes journal papers cheaper.”
@JoseServera
DeepDyve Freelancer | DeepDyve Pro | |
---|---|---|
Price | FREE | $49/month |
Save searches from | ||
Create folders to | ||
Export folders, citations | ||
Read DeepDyve articles | Abstract access only | Unlimited access to over |
20 pages / month | ||
PDF Discount | 20% off | |
Read and print from thousands of top scholarly journals.
Already have an account? Log in
Bookmark this article. You can see your Bookmarks on your DeepDyve Library.
To save an article, log in first, or sign up for a DeepDyve account if you don’t already have one.
Copy and paste the desired citation format or use the link below to download a file formatted for EndNote
EndNote
Export to EndNoteAll DeepDyve websites use cookies to improve your online experience. They were placed on your computer when you launched this website. You can change your cookie settings through your browser.
ok to continue