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) and discuss their functional implication in the immune and inflammatory response focusing on non ‐ IgE ‐ mediated activation mechanisms. This article is part of a series of reviews covering Mast cells and Basophils ...
, and vascular homeostasis. Immunoglobulin E receptor (FcεRI)- mediated mast cell activation is a well-studied and recognized mechanism of allergy and hypersensitivity reactions. However, non - IgE - mediated mast cell ...
Inflammation centered on non - IgE - mediated mast cell activation characterizes chronic spontaneous urticaria resistant to nonsedating H1-antihistamines. We recently uncovered a strong positive ...
with potentially life-threatening systemic anaphylactic reactions are one of the reasons for vaccine hesitancy. Recent studies have suggested that different mechanisms, including IgE - mediated and non - IgE - mediated ...
by intra-airway challenge with dinitrobenzene sulfonic acid (DNS). Acute bronchoconstriction and mast cell activation were observed shortly after challenge. Increased levels of the major mast cell mediator ...
Purpose of ReviewProvide an overview of the expanding landscape of mast cell (MC)–targeting treatments in mast cell activation syndromes (MCAS).Recent FindingsTyrosine-kinase inhibitors (TKIs ...
results in IgE binding to Fcε receptors on effector cells like mast cells and basophils. The activation of these cells causes release of histamine and other preformed mediators , and rapid symptom onset ...
of mast cell maturation influences the release of the preformed mediator histamine after mast cell activation and the density of FcεRI on the mast cell surface. The release of the de novo synthetized ...
cell activation both in vivo and in vitro, not much is known about the non -immunological ( IgE -independent) activation particularly in human mast cells . Mast cell IgE -independent activation is mediated ...
cells (from splenic non -B, non -T cells ), activated by IgE receptor cross-linking and/or IL-3 which results in IL-4 production by these cells . Furthermore, activated mast cells produce their own growth ...
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