Acta Biomaterialia 90 (2019) 112–121 Contents lists available at ScienceDirect Acta Biomaterialia journal homepage: www.elsevier.com/locate/actabiomat Full length article Nitric oxide releasing poly(vinylidene ﬂuoride-co-hexaﬂuoropropylene) ﬁlms using a ﬂuorinated nitric oxide donor to greatly decrease chemical leaching a a b a a b a Yang Zhou , Jinyi Tan , Jianfeng Wu , Qi Zhang , John Andre , Chuanwu Xi , Zhan Chen , a,⇑ Mark E. Meyerhoff Department of Chemistry, University of Michigan, Ann Arbor, MI 48109, USA Department of Environmental Health Sciences, University of Michigan, Ann Arbor, MI 48109, USA ar ti c l e i nf o ab stra ct Article history: Nitric oxide (NO) releasing polymers have been widely applied as biomaterials for a variety of biomedical Received 14 January 2019 implants and devices. However, the chemical leaching of NO donors and their byproduct species is almost Received in revised form 4 April 2019 always observed during the application of polymers doped with NO donors, unless the donor is covalently Accepted 9 April 2019 linked to the polymer. Herein, we report the ﬁrst NO releasing poly(vinylidene ﬂuoride-co- Available online 10 April 2019 hexaﬂuoropropylene) (PVDF-HFP) ﬂuorinated copolymer prepared by incorporating a ﬂuorinated S- nitrosothiol as the NO
Acta Biomaterialia – Elsevier
Published: May 1, 2019
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