Nitric oxide and the other cyclic nucleotide

Nitric oxide and the other cyclic nucleotide Nitric oxide (NO) participates in the regulation of the daily activities of cells as well as in cytotoxic events. Elucidating the mechanism(s) by which NO carries out its diverse functions has been the goal of numerous laboratories. In the cardiovascular system, evidence indicates that NO mediates its effects via an activation of soluble guanylyl cyclase (sGC). In other tissues, it is not clear if sGC is an exclusive target for NO or what the functions of cGMP might be. It is also unlikely that the diversity of NO actions is explained solely by changes in cGMP. This review focuses on the evidence that NO modulates cAMP signalling, with specific attention to the effects of NO on adenylyl cyclase (AC) as the target of NO regulation. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Cellular Signalling Elsevier

Nitric oxide and the other cyclic nucleotide

Cellular Signalling, Volume 14 (6) – Jun 1, 2002

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Publisher
Elsevier
Copyright
Copyright © 2002 Elsevier Science Inc.
ISSN
0898-6568
eISSN
1873-3913
DOI
10.1016/S0898-6568(01)00283-2
Publisher site
See Article on Publisher Site

Abstract

Nitric oxide (NO) participates in the regulation of the daily activities of cells as well as in cytotoxic events. Elucidating the mechanism(s) by which NO carries out its diverse functions has been the goal of numerous laboratories. In the cardiovascular system, evidence indicates that NO mediates its effects via an activation of soluble guanylyl cyclase (sGC). In other tissues, it is not clear if sGC is an exclusive target for NO or what the functions of cGMP might be. It is also unlikely that the diversity of NO actions is explained solely by changes in cGMP. This review focuses on the evidence that NO modulates cAMP signalling, with specific attention to the effects of NO on adenylyl cyclase (AC) as the target of NO regulation.

Journal

Cellular SignallingElsevier

Published: Jun 1, 2002

References

  • Eur J Pharmacol
    McKinney, M; Bolden, C; Smith, C; Johnson, A; Richelson, E
  • Neuropharmacology
    Hess, DT; Lin, LH; Freeman, JA; Norden, JJ
  • Biochem Pharmacol
    Merad-Boudia, M; Nicole, A; Sanliard-Baron, D; Saille, C; Ceballos-Picot, I
  • Neurology
    Jenner, P; Olanow, CW

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