•Nicotine decreases mice serum testosterone by triggering testicular autophagy instead of apoptosis via TCL1-mTOR-autophagy pathway in Leydig cells.•This study is among the first to use bioinformatics in the reproductive research area to draw the relationship between nicotine and testicular autophagy.•This work as determined the relationship between nicotine and changes of testosterone concentrations in mouse sera on a molecular level.•It was also found that the TCL1 promoter is methylated consequent to a cascade pathway induced by the presence of nicotine.
The International Journal of Biochemistry & Cell Biology – Elsevier
Published: Jul 1, 2018
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