Article history: Background: Unilateral vestibular deafferentation syndrome (uVDS) holds a particular place in the Received 24 July 2017 vestibular pathology domain. Due to its suddenness, the violence of its symptoms that often result in Received in revised form 6 September 2017 emergency hospitalization, and its associated original neurophysiological properties, this syndrome is a Accepted 11 September 2017 major source of questioning for the otoneurology community. Also, its putative pathogenic causes remain Available online 11 September 2017 to be determined. There is currently a strong medical need for the development of targeted and effective countermeasures to improve the therapeutic management of uVDS. Keywords: New methods: The present study reports the development of a new mouse model for inducing and Vestibule evaluating uVDS. Both the method for generating controlled excitotoxic-type peripheral vestibular dam- Vestibular syndrome ages, through transtympanic administration of the glutamate receptors agonist kainate (TTK), and the Vertigo procedure for evaluating the ensuing clinical signs are detailed. Comparison with existing methods: Through extensive analysis of the clinical symptoms characteristics, this new animal model provides the opportunity to better follow the temporal evolution of various uVDS speciﬁc symptoms, while better appreciating the different phases that composed this syndrome. Results: The uVDS
Journal of Neuroscience Methods – Elsevier
Published: Jan 1, 2018
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