New mouse model for inducing and evaluating unilateral vestibular deafferentation syndrome

New mouse model for inducing and evaluating unilateral vestibular deafferentation syndrome Article history: Background: Unilateral vestibular deafferentation syndrome (uVDS) holds a particular place in the Received 24 July 2017 vestibular pathology domain. Due to its suddenness, the violence of its symptoms that often result in Received in revised form 6 September 2017 emergency hospitalization, and its associated original neurophysiological properties, this syndrome is a Accepted 11 September 2017 major source of questioning for the otoneurology community. Also, its putative pathogenic causes remain Available online 11 September 2017 to be determined. There is currently a strong medical need for the development of targeted and effective countermeasures to improve the therapeutic management of uVDS. Keywords: New methods: The present study reports the development of a new mouse model for inducing and Vestibule evaluating uVDS. Both the method for generating controlled excitotoxic-type peripheral vestibular dam- Vestibular syndrome ages, through transtympanic administration of the glutamate receptors agonist kainate (TTK), and the Vertigo procedure for evaluating the ensuing clinical signs are detailed. Comparison with existing methods: Through extensive analysis of the clinical symptoms characteristics, this new animal model provides the opportunity to better follow the temporal evolution of various uVDS specific symptoms, while better appreciating the different phases that composed this syndrome. Results: The uVDS http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Journal of Neuroscience Methods Elsevier

New mouse model for inducing and evaluating unilateral vestibular deafferentation syndrome

Loading next page...
 
/lp/elsevier/new-mouse-model-for-inducing-and-evaluating-unilateral-vestibular-QBKVxgKhHD
Publisher
Elsevier
Copyright
Copyright © 2017 Elsevier B.V.
ISSN
0165-0270
eISSN
1872-678X
D.O.I.
10.1016/j.jneumeth.2017.09.002
Publisher site
See Article on Publisher Site

Abstract

Article history: Background: Unilateral vestibular deafferentation syndrome (uVDS) holds a particular place in the Received 24 July 2017 vestibular pathology domain. Due to its suddenness, the violence of its symptoms that often result in Received in revised form 6 September 2017 emergency hospitalization, and its associated original neurophysiological properties, this syndrome is a Accepted 11 September 2017 major source of questioning for the otoneurology community. Also, its putative pathogenic causes remain Available online 11 September 2017 to be determined. There is currently a strong medical need for the development of targeted and effective countermeasures to improve the therapeutic management of uVDS. Keywords: New methods: The present study reports the development of a new mouse model for inducing and Vestibule evaluating uVDS. Both the method for generating controlled excitotoxic-type peripheral vestibular dam- Vestibular syndrome ages, through transtympanic administration of the glutamate receptors agonist kainate (TTK), and the Vertigo procedure for evaluating the ensuing clinical signs are detailed. Comparison with existing methods: Through extensive analysis of the clinical symptoms characteristics, this new animal model provides the opportunity to better follow the temporal evolution of various uVDS specific symptoms, while better appreciating the different phases that composed this syndrome. Results: The uVDS

Journal

Journal of Neuroscience MethodsElsevier

Published: Jan 1, 2018

References

You’re reading a free preview. Subscribe to read the entire article.


DeepDyve is your
personal research library

It’s your single place to instantly
discover and read the research
that matters to you.

Enjoy affordable access to
over 18 million articles from more than
15,000 peer-reviewed journals.

All for just $49/month

Explore the DeepDyve Library

Search

Query the DeepDyve database, plus search all of PubMed and Google Scholar seamlessly

Organize

Save any article or search result from DeepDyve, PubMed, and Google Scholar... all in one place.

Access

Get unlimited, online access to over 18 million full-text articles from more than 15,000 scientific journals.

Your journals are on DeepDyve

Read from thousands of the leading scholarly journals from SpringerNature, Elsevier, Wiley-Blackwell, Oxford University Press and more.

All the latest content is available, no embargo periods.

See the journals in your area

DeepDyve

Freelancer

DeepDyve

Pro

Price

FREE

$49/month
$360/year

Save searches from
Google Scholar,
PubMed

Create lists to
organize your research

Export lists, citations

Read DeepDyve articles

Abstract access only

Unlimited access to over
18 million full-text articles

Print

20 pages / month

PDF Discount

20% off