Bioorganic & Medicinal Chemistry Letters 28 (2018) 1106–1110 Contents lists available at ScienceDirect Bioorganic & Medicinal Chemistry Letters journal homepage: www.elsevier.com/locate/bmcl New 4-aryl-1,3,2-oxathiazolylium-5-olates: Chemical synthesis and photochemical stability of a novel series of S-nitrosothiols a b a,⇑ Monica Eilertsen , Steve M. Allin , Russell J. Pearson School of Pharmacy, Keele University, Hornbeam Building, Keele, Staffordshire ST5 5BG, UK Department of Chemistry and Forensics, School of Science and Technology, Nottingham Trent University, Nottingham NG11 8NS, UK ar ti c l e i nf o ab stra ct Article history: S-nitrosothiols (RSNOs) remain one of the most popular classes of NO-donating compounds due to their Received 3 November 2017 ability to release nitric oxide (NO) under non-enzymatic means whilst producing an inert disulphide by- Revised 25 January 2018 product. However, alligning these compounds to the different biological ﬁelds of NO research has proved Accepted 27 January 2018 to be problematic due to the inherent instability of such compounds under a variety of conditions includ- Available online 31 January 2018 ing heat, light and the presence of copper ions. 1,3,2-Oxathiazolylium-5-olates (OZOs) represent an inter- esting subclass of S-nitrosothiols that lock the –SNO moiety into a ﬁve membered heterocyclic ring in an
Bioorganic & Medicinal Chemistry Letters – Elsevier
Published: Apr 1, 2018
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