New 4-aryl-1,3,2-oxathiazolylium-5-olates: Chemical synthesis and photochemical stability of a novel series of S-nitrosothiols

New 4-aryl-1,3,2-oxathiazolylium-5-olates: Chemical synthesis and photochemical stability of a... Bioorganic & Medicinal Chemistry Letters 28 (2018) 1106–1110 Contents lists available at ScienceDirect Bioorganic & Medicinal Chemistry Letters journal homepage: www.elsevier.com/locate/bmcl New 4-aryl-1,3,2-oxathiazolylium-5-olates: Chemical synthesis and photochemical stability of a novel series of S-nitrosothiols a b a,⇑ Monica Eilertsen , Steve M. Allin , Russell J. Pearson School of Pharmacy, Keele University, Hornbeam Building, Keele, Staffordshire ST5 5BG, UK Department of Chemistry and Forensics, School of Science and Technology, Nottingham Trent University, Nottingham NG11 8NS, UK ar ti c l e i nf o ab stra ct Article history: S-nitrosothiols (RSNOs) remain one of the most popular classes of NO-donating compounds due to their Received 3 November 2017 ability to release nitric oxide (NO) under non-enzymatic means whilst producing an inert disulphide by- Revised 25 January 2018 product. However, alligning these compounds to the different biological fields of NO research has proved Accepted 27 January 2018 to be problematic due to the inherent instability of such compounds under a variety of conditions includ- Available online 31 January 2018 ing heat, light and the presence of copper ions. 1,3,2-Oxathiazolylium-5-olates (OZOs) represent an inter- esting subclass of S-nitrosothiols that lock the –SNO moiety into a five membered heterocyclic ring in an http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Bioorganic & Medicinal Chemistry Letters Elsevier

New 4-aryl-1,3,2-oxathiazolylium-5-olates: Chemical synthesis and photochemical stability of a novel series of S-nitrosothiols

Loading next page...
 
/lp/elsevier/new-4-aryl-1-3-2-oxathiazolylium-5-olates-chemical-synthesis-and-Pkmt9Zb1OY
Publisher
Elsevier
Copyright
Copyright © 2018 The Author(s)
ISSN
0960-894x
D.O.I.
10.1016/j.bmcl.2018.01.059
Publisher site
See Article on Publisher Site

Abstract

Bioorganic & Medicinal Chemistry Letters 28 (2018) 1106–1110 Contents lists available at ScienceDirect Bioorganic & Medicinal Chemistry Letters journal homepage: www.elsevier.com/locate/bmcl New 4-aryl-1,3,2-oxathiazolylium-5-olates: Chemical synthesis and photochemical stability of a novel series of S-nitrosothiols a b a,⇑ Monica Eilertsen , Steve M. Allin , Russell J. Pearson School of Pharmacy, Keele University, Hornbeam Building, Keele, Staffordshire ST5 5BG, UK Department of Chemistry and Forensics, School of Science and Technology, Nottingham Trent University, Nottingham NG11 8NS, UK ar ti c l e i nf o ab stra ct Article history: S-nitrosothiols (RSNOs) remain one of the most popular classes of NO-donating compounds due to their Received 3 November 2017 ability to release nitric oxide (NO) under non-enzymatic means whilst producing an inert disulphide by- Revised 25 January 2018 product. However, alligning these compounds to the different biological fields of NO research has proved Accepted 27 January 2018 to be problematic due to the inherent instability of such compounds under a variety of conditions includ- Available online 31 January 2018 ing heat, light and the presence of copper ions. 1,3,2-Oxathiazolylium-5-olates (OZOs) represent an inter- esting subclass of S-nitrosothiols that lock the –SNO moiety into a five membered heterocyclic ring in an

Journal

Bioorganic & Medicinal Chemistry LettersElsevier

Published: Apr 1, 2018

References

You’re reading a free preview. Subscribe to read the entire article.


DeepDyve is your
personal research library

It’s your single place to instantly
discover and read the research
that matters to you.

Enjoy affordable access to
over 18 million articles from more than
15,000 peer-reviewed journals.

All for just $49/month

Explore the DeepDyve Library

Search

Query the DeepDyve database, plus search all of PubMed and Google Scholar seamlessly

Organize

Save any article or search result from DeepDyve, PubMed, and Google Scholar... all in one place.

Access

Get unlimited, online access to over 18 million full-text articles from more than 15,000 scientific journals.

Your journals are on DeepDyve

Read from thousands of the leading scholarly journals from SpringerNature, Elsevier, Wiley-Blackwell, Oxford University Press and more.

All the latest content is available, no embargo periods.

See the journals in your area

DeepDyve

Freelancer

DeepDyve

Pro

Price

FREE

$49/month
$360/year

Save searches from
Google Scholar,
PubMed

Create lists to
organize your research

Export lists, citations

Read DeepDyve articles

Abstract access only

Unlimited access to over
18 million full-text articles

Print

20 pages / month

PDF Discount

20% off