New 4-aryl-1,3,2-oxathiazolylium-5-olates: Chemical synthesis and photochemical stability of a novel series of S-nitrosothiols

New 4-aryl-1,3,2-oxathiazolylium-5-olates: Chemical synthesis and photochemical stability of a... Bioorganic & Medicinal Chemistry Letters 28 (2018) 1106–1110 Contents lists available at ScienceDirect Bioorganic & Medicinal Chemistry Letters journal homepage: www.elsevier.com/locate/bmcl New 4-aryl-1,3,2-oxathiazolylium-5-olates: Chemical synthesis and photochemical stability of a novel series of S-nitrosothiols a b a,⇑ Monica Eilertsen , Steve M. Allin , Russell J. Pearson School of Pharmacy, Keele University, Hornbeam Building, Keele, Staffordshire ST5 5BG, UK Department of Chemistry and Forensics, School of Science and Technology, Nottingham Trent University, Nottingham NG11 8NS, UK ar ti c l e i nf o ab stra ct Article history: S-nitrosothiols (RSNOs) remain one of the most popular classes of NO-donating compounds due to their Received 3 November 2017 ability to release nitric oxide (NO) under non-enzymatic means whilst producing an inert disulphide by- Revised 25 January 2018 product. However, alligning these compounds to the different biological fields of NO research has proved Accepted 27 January 2018 to be problematic due to the inherent instability of such compounds under a variety of conditions includ- Available online 31 January 2018 ing heat, light and the presence of copper ions. 1,3,2-Oxathiazolylium-5-olates (OZOs) represent an inter- esting subclass of S-nitrosothiols that lock the –SNO moiety into a five membered heterocyclic ring in an http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Bioorganic & Medicinal Chemistry Letters Elsevier

New 4-aryl-1,3,2-oxathiazolylium-5-olates: Chemical synthesis and photochemical stability of a novel series of S-nitrosothiols

Loading next page...
 
/lp/elsevier/new-4-aryl-1-3-2-oxathiazolylium-5-olates-chemical-synthesis-and-Pkmt9Zb1OY
Publisher
Elsevier
Copyright
Copyright © 2018 The Author(s)
ISSN
0960-894x
D.O.I.
10.1016/j.bmcl.2018.01.059
Publisher site
See Article on Publisher Site

Abstract

Bioorganic & Medicinal Chemistry Letters 28 (2018) 1106–1110 Contents lists available at ScienceDirect Bioorganic & Medicinal Chemistry Letters journal homepage: www.elsevier.com/locate/bmcl New 4-aryl-1,3,2-oxathiazolylium-5-olates: Chemical synthesis and photochemical stability of a novel series of S-nitrosothiols a b a,⇑ Monica Eilertsen , Steve M. Allin , Russell J. Pearson School of Pharmacy, Keele University, Hornbeam Building, Keele, Staffordshire ST5 5BG, UK Department of Chemistry and Forensics, School of Science and Technology, Nottingham Trent University, Nottingham NG11 8NS, UK ar ti c l e i nf o ab stra ct Article history: S-nitrosothiols (RSNOs) remain one of the most popular classes of NO-donating compounds due to their Received 3 November 2017 ability to release nitric oxide (NO) under non-enzymatic means whilst producing an inert disulphide by- Revised 25 January 2018 product. However, alligning these compounds to the different biological fields of NO research has proved Accepted 27 January 2018 to be problematic due to the inherent instability of such compounds under a variety of conditions includ- Available online 31 January 2018 ing heat, light and the presence of copper ions. 1,3,2-Oxathiazolylium-5-olates (OZOs) represent an inter- esting subclass of S-nitrosothiols that lock the –SNO moiety into a five membered heterocyclic ring in an

Journal

Bioorganic & Medicinal Chemistry LettersElsevier

Published: Apr 1, 2018

References

You’re reading a free preview. Subscribe to read the entire article.


DeepDyve is your
personal research library

It’s your single place to instantly
discover and read the research
that matters to you.

Enjoy affordable access to
over 12 million articles from more than
10,000 peer-reviewed journals.

All for just $49/month

Explore the DeepDyve Library

Unlimited reading

Read as many articles as you need. Full articles with original layout, charts and figures. Read online, from anywhere.

Stay up to date

Keep up with your field with Personalized Recommendations and Follow Journals to get automatic updates.

Organize your research

It’s easy to organize your research with our built-in tools.

Your journals are on DeepDyve

Read from thousands of the leading scholarly journals from SpringerNature, Elsevier, Wiley-Blackwell, Oxford University Press and more.

All the latest content is available, no embargo periods.

See the journals in your area

Monthly Plan

  • Read unlimited articles
  • Personalized recommendations
  • No expiration
  • Print 20 pages per month
  • 20% off on PDF purchases
  • Organize your research
  • Get updates on your journals and topic searches

$49/month

Start Free Trial

14-day Free Trial

Best Deal — 39% off

Annual Plan

  • All the features of the Professional Plan, but for 39% off!
  • Billed annually
  • No expiration
  • For the normal price of 10 articles elsewhere, you get one full year of unlimited access to articles.

$588

$360/year

billed annually
Start Free Trial

14-day Free Trial