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similar to the acute ET-1 injections and comparable to other models of retinal ischemia . Compensatory changes were observed, including an increase in calcitonin gene- related peptide (CGRP) gene expression ...
broadly in retinal neurons including retinal ganglion cells (RGCs) and loss of p58IPK results in age- related RGC degeneration. In the present study, we investigate the role of p58IPK in neuroprotection ...
. It is of our great interest to know whether pilocarpine has the additional properties of retinal neuroprotection independent of IOP lowering in vitro and in vivo models. Methods In rat primary retinal cultures ...
. The newly discovered docosahexaenoic acid signaling pathways, as well as other lipid messengers related to synaptic activation, may lead to the clarification of clinical issues relevant to stroke, age- related ...
photoreceptor preservation after retinal separation from the RPE. Clinical Relevance Fas-pathway inhibition might serve as a novel mechanism for preserving photoreceptor cells during retinal disease ...
retinal ganglion cell death.Recent advances in elucidating the mechanisms of cell death in ischemic and neurodegenerative central nervous system diseases are relevant to mechanisms of cell death in glaucoma ...
Abstract The development of neuroprotective strategies to attenuate retinal ganglion cell death could lead to novel therapies for chronic optic neuropathies such as glaucoma. Intravitreal ...
the miRNAs’ expressions in MS and control brain samples at different lesional stages in white versus grey matter regions. In active MS lesions, we found upregulation of ischemia - related miRNAs in white ...
induced neuroenhancement (improvement in RGCs function and neural conduction along visual pathways related to improvement of visual field defects) and neuroprotection (unmodified or improved RNFL ...
neovascularization is related to these dark areas of peripheral retinal ischemia . Treatment of retinal neovascularization involves laser panretinal photocoagulation which destroys an oxygen sink, the photoreceptors ...
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