Neuropeptide Y Y 5 receptor antagonist CGP71683A: the effects on food intake and anxiety-related behavior in the rat

Neuropeptide Y Y 5 receptor antagonist CGP71683A: the effects on food intake and anxiety-related... The effects of neuropeptide Y Y 5 receptor antagonist ( trans -naphtalene-1-sulphonic acid {4-((4-amino-quinazolin-2-ylamino)-methyl)-cyclohexylmethyl}-amide hydrochloride; CGP71683A), on food intake, anxiety and locomotor activity were studied. CGP71683A (1–10 mg/kg, i.p.) dose-dependently decreased nocturnal and fasting-induced food intake. CGP71683A did not have an anxiogenic-like effect in the rat social interaction test. In the elevated plus-maze test, where novel neuropeptide Y Y 1 receptor antagonist (2 R )-5-((amino(imino)methyl}amino)-2-((2.2-diphenylacetyl)-amino)- N -((1 R )-1-(4-hydroxyphenyl)ethyl-pentanamide (H 409/22) had anxiogenic-like effect, CGP71683A was inactive. In the open-field test, carried out immediately after the elevated plus-maze test, CGP71683A inhibited horizontal and vertical activity. CGP71683A did modify the habituation of locomotor response in novel environment. These data show that the inhibition of food intake induced by CGP71683A could not be explained by increased fearfulness, a state that is induced by neuropeptide Y Y 1 receptor antagonists. Thus, our data, obtained with first neuropeptide Y Y 5 receptor antagonist CGP71683A, suggest that in contrast to the neuropeptide Y Y 1 receptor, Y 5 receptor is not involved in tonic neuropeptide Y-induced anxiolysis. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png European Journal of Pharmacology Elsevier

Neuropeptide Y Y 5 receptor antagonist CGP71683A: the effects on food intake and anxiety-related behavior in the rat

Loading next page...
 
/lp/elsevier/neuropeptide-y-y-5-receptor-antagonist-cgp71683a-the-effects-on-food-NwHUI7HY0U
Publisher
Elsevier
Copyright
Copyright © 2001 Elsevier Ltd
ISSN
0014-2999
DOI
10.1016/S0014-2999(01)00768-3
Publisher site
See Article on Publisher Site

Abstract

The effects of neuropeptide Y Y 5 receptor antagonist ( trans -naphtalene-1-sulphonic acid {4-((4-amino-quinazolin-2-ylamino)-methyl)-cyclohexylmethyl}-amide hydrochloride; CGP71683A), on food intake, anxiety and locomotor activity were studied. CGP71683A (1–10 mg/kg, i.p.) dose-dependently decreased nocturnal and fasting-induced food intake. CGP71683A did not have an anxiogenic-like effect in the rat social interaction test. In the elevated plus-maze test, where novel neuropeptide Y Y 1 receptor antagonist (2 R )-5-((amino(imino)methyl}amino)-2-((2.2-diphenylacetyl)-amino)- N -((1 R )-1-(4-hydroxyphenyl)ethyl-pentanamide (H 409/22) had anxiogenic-like effect, CGP71683A was inactive. In the open-field test, carried out immediately after the elevated plus-maze test, CGP71683A inhibited horizontal and vertical activity. CGP71683A did modify the habituation of locomotor response in novel environment. These data show that the inhibition of food intake induced by CGP71683A could not be explained by increased fearfulness, a state that is induced by neuropeptide Y Y 1 receptor antagonists. Thus, our data, obtained with first neuropeptide Y Y 5 receptor antagonist CGP71683A, suggest that in contrast to the neuropeptide Y Y 1 receptor, Y 5 receptor is not involved in tonic neuropeptide Y-induced anxiolysis.

Journal

European Journal of PharmacologyElsevier

Published: Mar 2, 2001

References

You’re reading a free preview. Subscribe to read the entire article.


DeepDyve is your
personal research library

It’s your single place to instantly
discover and read the research
that matters to you.

Enjoy affordable access to
over 18 million articles from more than
15,000 peer-reviewed journals.

All for just $49/month

Explore the DeepDyve Library

Search

Query the DeepDyve database, plus search all of PubMed and Google Scholar seamlessly

Organize

Save any article or search result from DeepDyve, PubMed, and Google Scholar... all in one place.

Access

Get unlimited, online access to over 18 million full-text articles from more than 15,000 scientific journals.

Your journals are on DeepDyve

Read from thousands of the leading scholarly journals from SpringerNature, Elsevier, Wiley-Blackwell, Oxford University Press and more.

All the latest content is available, no embargo periods.

See the journals in your area

DeepDyve

Freelancer

DeepDyve

Pro

Price

FREE

$49/month
$360/year

Save searches from
Google Scholar,
PubMed

Create folders to
organize your research

Export folders, citations

Read DeepDyve articles

Abstract access only

Unlimited access to over
18 million full-text articles

Print

20 pages / month

PDF Discount

20% off