Neuropeptide Y Y 1 receptor antagonist BIBP3226 produces conditioned place aversion in rats

Neuropeptide Y Y 1 receptor antagonist BIBP3226 produces conditioned place aversion in rats 1. 1. Previous studies have shown that the blockade of the neuropeptide Y (NPY) y 1 receptors with N 2 - (diphenylacetyl)- N -((4-hydroxy-phenyl)methyl)-D-arginine amide (BIBP3226) induces anxiogenic-like reaction in rats tested in elevated plus-maze test. 2. 2. The present study examined whether such a treatment is aversive using place conditioning in a two- compartment apparatus. Locomotor activity was measured in open field test. 3. 3. Pairings with potentially anxiogenic dose of BIBP3226 (5μg/6.5μl I.c.v.) produced a conditioned aversion for the drug-associated place, whereas the locomotor activity in the open field test was not affected by this dose of BIBP3226. 4. 4. These data suggest that the blockade of central NPY y 1 receptors is aversive and provide additional evidence to the hypothesis that the NPY y 1 receptors are involved in the regulation of affective states. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Progress in Neuro-Psychopharmacology & Biological Psychiatry Elsevier

Neuropeptide Y Y 1 receptor antagonist BIBP3226 produces conditioned place aversion in rats

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Publisher
Elsevier
Copyright
Copyright © 1999 Elsevier Ltd
ISSN
0278-5846
eISSN
1878-4216
DOI
10.1016/S0278-5846(99)00029-9
Publisher site
See Article on Publisher Site

Abstract

1. 1. Previous studies have shown that the blockade of the neuropeptide Y (NPY) y 1 receptors with N 2 - (diphenylacetyl)- N -((4-hydroxy-phenyl)methyl)-D-arginine amide (BIBP3226) induces anxiogenic-like reaction in rats tested in elevated plus-maze test. 2. 2. The present study examined whether such a treatment is aversive using place conditioning in a two- compartment apparatus. Locomotor activity was measured in open field test. 3. 3. Pairings with potentially anxiogenic dose of BIBP3226 (5μg/6.5μl I.c.v.) produced a conditioned aversion for the drug-associated place, whereas the locomotor activity in the open field test was not affected by this dose of BIBP3226. 4. 4. These data suggest that the blockade of central NPY y 1 receptors is aversive and provide additional evidence to the hypothesis that the NPY y 1 receptors are involved in the regulation of affective states.

Journal

Progress in Neuro-Psychopharmacology & Biological PsychiatryElsevier

Published: May 1, 1999

References

  • Anxiogenic-Like Effect of the NPY Y 1 , Receptor Antagonist BIBP3226 Administered into the Dorsal Periaqueductal Gray Matter in Rats
    Kask, A.; Rägo, L.; Harro, J.
  • Structural Diversity of Receptors for Neuropeptide Y, Peptide YY and Pancreatic Polypeptide
    Larhammar, D.
  • Molecular Approaches to the Discovery of New Treatments for Obesity
    Strader, C.D.; Macintyre, D.E.; Candelore, M.R.; Parker, E.M.
  • Neuropeptide Y and Related Peptides
    Wahlestedt, C.; Heilig, M.

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