Neurological condition in 18-month-old children perinatally exposed to polychlorinated biphenyls and dioxins

Neurological condition in 18-month-old children perinatally exposed to polychlorinated biphenyls... The neurological optimality of 418 Dutch children was evaluated at the age of 18 months, in order to determine whether prenatal and breast milk mediated exposure to polychlorinated biphenyls (PCBs) and dioxins affected neurological development. Half of the infants were breast-fed, the other half were formula-fed. PCB concentrations in cord and maternal plasma were used as a measure of prenatal exposure to PCBs. To measure postnatal exposure, PCB and dioxin congeners were determined in human milk and in formula milk. After adjusting for covariates, transplacental PCB exposure was negatively related to the neurological condition at 18 months. Although greater amounts of PCBs and dioxins are transferred via nursing than via placental passage, an effect of lactational exposure to PCBs and dioxins could not be detected. We even found a beneficial effect of breast-feeding on the fluency of movements. We conclude that transplacental PCB passage has a small negative effect on the neurological condition in 18-month-old toddlers. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Early Human Development Elsevier

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Publisher
Elsevier
Copyright
Copyright © 1995 Elsevier Ltd
ISSN
0378-3782
DOI
10.1016/0378-3782(95)01674-0
Publisher site
See Article on Publisher Site

Abstract

The neurological optimality of 418 Dutch children was evaluated at the age of 18 months, in order to determine whether prenatal and breast milk mediated exposure to polychlorinated biphenyls (PCBs) and dioxins affected neurological development. Half of the infants were breast-fed, the other half were formula-fed. PCB concentrations in cord and maternal plasma were used as a measure of prenatal exposure to PCBs. To measure postnatal exposure, PCB and dioxin congeners were determined in human milk and in formula milk. After adjusting for covariates, transplacental PCB exposure was negatively related to the neurological condition at 18 months. Although greater amounts of PCBs and dioxins are transferred via nursing than via placental passage, an effect of lactational exposure to PCBs and dioxins could not be detected. We even found a beneficial effect of breast-feeding on the fluency of movements. We conclude that transplacental PCB passage has a small negative effect on the neurological condition in 18-month-old toddlers.

Journal

Early Human DevelopmentElsevier

Published: Oct 2, 1995

References

  • The transfer of polychlorinated biphenyls (PCBs) and polybrominated biphenyls (PBBs) across the human placenta and into maternal milk
    Jacobson, J.L.; Fein, G.G.; Jacobson, S.W.; Schwartz, P.M.; Dowler, J.K.
  • Perinatal exposure to polychlorinated biphenyls and dioxins and its effect on neonatal neurological development
    Huisman, M.; Koopman-Esseboom, C.; Fidler, V.; Hadders-Algra, M.; Paauw, C.G.van der; Tuinstra, L.G.M.Th.
  • The development of crawling between 18 months and four years
    Touwen, B.C.L.; Hempel, M.S.; Westra, L.C.

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