Neurokinin-3 receptors modulate dopamine cell function and alter the effects of 6-hydroxydopamine

Neurokinin-3 receptors modulate dopamine cell function and alter the effects of 6-hydroxydopamine Neurokinin-3 receptor expression within rat midbrain dopamine neurons was demonstrated using a combination of in situ hybridization and receptor autoradiographic techniques. Continuous intranigral infusion of the neurokinin-3 receptor agonist senktide selectively increased striatal dopamine metabolism over a period of several days, followed by the apparent development of tolerance. In contrast, in animals with moderate unilateral 6-hydroxydopamine-induced lesions of nigrostriatal dopamine cells, intranigral senktide infusion increased dopamine turnover in the surviving dopamine neurons and reduced functional dopamine asymmetry (reflected by spontaneous rotations) over the 2-week period tested. Thus nigral neurokinin receptors can modulate normal dopamine cell activity and may provide a therapeutic target in the treatment of Parkinson's disease. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Brain Research Elsevier

Neurokinin-3 receptors modulate dopamine cell function and alter the effects of 6-hydroxydopamine

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Publisher
Elsevier
Copyright
Copyright © 1995 Elsevier Ltd
ISSN
0006-8993
D.O.I.
10.1016/0006-8993(95)00791-N
Publisher site
See Article on Publisher Site

Abstract

Neurokinin-3 receptor expression within rat midbrain dopamine neurons was demonstrated using a combination of in situ hybridization and receptor autoradiographic techniques. Continuous intranigral infusion of the neurokinin-3 receptor agonist senktide selectively increased striatal dopamine metabolism over a period of several days, followed by the apparent development of tolerance. In contrast, in animals with moderate unilateral 6-hydroxydopamine-induced lesions of nigrostriatal dopamine cells, intranigral senktide infusion increased dopamine turnover in the surviving dopamine neurons and reduced functional dopamine asymmetry (reflected by spontaneous rotations) over the 2-week period tested. Thus nigral neurokinin receptors can modulate normal dopamine cell activity and may provide a therapeutic target in the treatment of Parkinson's disease.

Journal

Brain ResearchElsevier

Published: Oct 9, 1995

References

  • In situ hybridization of trkB and trkC receptor mRNA in rat forebrain and association with high-affinity binding of ( 125 I)BDNF, ( 125 I)NT-4/5 and ( 125 I)NT-3
    Altar, C.A.; Siuciak, J.A.; Wright, P.; Ip, N.Y.; Lindsay, R.M.; Wiegand, S.J.
  • Behavioral indices of moderate nigro-striatal 6-hydroxydopamine lesion: a preclinical Parkinson's model
    Fornaguera, J.; Schwarting, R.K.W.; Boix, F.; Huston, J.P.
  • Thyrotropin-releasing hormone (TRH) counteracts the neuronal damage induced by a substance P antagonist
    Freedman, J.; Hokfelt, T.; Jonsson, G.; Post, C.
  • Stimulatory effects of substance P on neurite extension and cyclic AMP levels in cultured neuroblastoma cells
    Narumi, S.; Maki, Y.

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