Neuroimmune and epithelial interactions in intestinal inflammation

Neuroimmune and epithelial interactions in intestinal inflammation The gastrointestinal tract contains the most extensive immune system in the body as well as the largest and most diverse collection of nerves outside of the central nervous system. These systems are continuously involved in ongoing physiological activities of the bowel and they play an active role in pathophysiological processes. It is becoming increasingly clear that intestinal inflammation involves a dynamic interplay between at least three different cell systems: immune cells, neurons and mucosal epithelial cells. A wide array of signalling molecules, including cytokines, neurotransmitters and neurotrophic factors mediate the exchange of information between these cells. Neuroimmune-epithelial interactions that take place in the wall of the gut explain many of pathophysiological features of intestinal inflammation. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Current Opinion in Pharmacology Elsevier

Neuroimmune and epithelial interactions in intestinal inflammation

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Publisher
Elsevier
Copyright
Copyright © 2002 Elsevier Science Ltd
ISSN
1471-4892
D.O.I.
10.1016/S1471-4892(02)00215-1
Publisher site
See Article on Publisher Site

Abstract

The gastrointestinal tract contains the most extensive immune system in the body as well as the largest and most diverse collection of nerves outside of the central nervous system. These systems are continuously involved in ongoing physiological activities of the bowel and they play an active role in pathophysiological processes. It is becoming increasingly clear that intestinal inflammation involves a dynamic interplay between at least three different cell systems: immune cells, neurons and mucosal epithelial cells. A wide array of signalling molecules, including cytokines, neurotransmitters and neurotrophic factors mediate the exchange of information between these cells. Neuroimmune-epithelial interactions that take place in the wall of the gut explain many of pathophysiological features of intestinal inflammation.

Journal

Current Opinion in PharmacologyElsevier

Published: Dec 1, 2002

References

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