Nerve Growth Factor, Central Nervous System Apoptosis, and Adrenocortical Activity in Aged Fischer-344/Brown Norway F1 Hybrid Rats

Nerve Growth Factor, Central Nervous System Apoptosis, and Adrenocortical Activity in Aged... During aging there is a progressive loss of neuronal function in the basal forebrain that results in cognitive impairment and cholinergic deficits. While altered neurotrophin (NT)-mediated signal transduction may account for some age-associated deficits, there are differences in the extent of NT responsiveness among different laboratory rat strains. Here we measured nerve growth factor (NGF) protein levels and fragmented DNA in the CNS, and basal and NGF-stimulated activity levels of the hypothalamus-pituitary-adrenocortical axis (HPAA) in 3-, 18-, and 30-month-old Fischer-344/Brown Norway rats. Our results show that while there is no age-associated differences in NGF protein levels, in aged Fischer-344/Brown Norway rats, there are increases in levels of immunoreactive fragmented DNA in the CNS and in adrenocortical responses to the peripheral administration of NGF. These data contribute to the characterization of the Fischer-344/Brown Norway F1 hybrid rat and provide baseline values useful for future studies on aged CNS. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Brain Research Bulletin Elsevier

Nerve Growth Factor, Central Nervous System Apoptosis, and Adrenocortical Activity in Aged Fischer-344/Brown Norway F1 Hybrid Rats

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Publisher
Elsevier
Copyright
Copyright © 1997 Elsevier Science Inc.
ISSN
0361-9230
eISSN
1873-2747
D.O.I.
10.1016/S0361-9230(97)00001-4
Publisher site
See Article on Publisher Site

Abstract

During aging there is a progressive loss of neuronal function in the basal forebrain that results in cognitive impairment and cholinergic deficits. While altered neurotrophin (NT)-mediated signal transduction may account for some age-associated deficits, there are differences in the extent of NT responsiveness among different laboratory rat strains. Here we measured nerve growth factor (NGF) protein levels and fragmented DNA in the CNS, and basal and NGF-stimulated activity levels of the hypothalamus-pituitary-adrenocortical axis (HPAA) in 3-, 18-, and 30-month-old Fischer-344/Brown Norway rats. Our results show that while there is no age-associated differences in NGF protein levels, in aged Fischer-344/Brown Norway rats, there are increases in levels of immunoreactive fragmented DNA in the CNS and in adrenocortical responses to the peripheral administration of NGF. These data contribute to the characterization of the Fischer-344/Brown Norway F1 hybrid rat and provide baseline values useful for future studies on aged CNS.

Journal

Brain Research BulletinElsevier

Published: Jan 1, 1997

References

  • Nerve growth factor binding in aged rat central nervous system: Effect of acetyl- l -carnitine
    Angelucci, L.; Ramacci, M.T.; Taglialatela, G.; Hulsebosch, C.; Morgan, B.; Werrbach-Perez, K.; Perez-Polo, J.R.
  • Neurotrophic factors and their receptors
    Barbacid, M.
  • Role of neurotrophic factors in neuronal development
    Henderson, C.E.
  • Physiology of the neurotrophins
    Lewin, G.R.; Barde, Y.A.
  • Regional uptake of blood-borne nerve growth factor
    Loy, R.; Taglialatela, G.; Angelucci, L.; Heyer, D.; Perez-Polo, J.R.
  • Hippocampal vulnerability to stress and aging: Possible role of neurotrophic factors
    Smith, M.A.

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