Neonatally administered naltrexone affects several behavioral responses in adult rats of both genders

Neonatally administered naltrexone affects several behavioral responses in adult rats of both... The effects of a daily injection of the opioid antagonist naltrexone (NALTX, 1 mg/kg SC), from birth to weaning day, on several behavioral parameters were investigated in adult rats of both genders. This work uses three behavioral tests. The use of the open-field test in addition to the holeboard and plus-maze tests allows the measurement of complementary parameters, and provided further information on diverse components of behavior. The effect of repeated testing (habituation) over 3 consecutive days of open-field testing was also assessed. In accordance with previous reports, female rats showed higher locomotor activity and exploration and a lower level of emotionality than their male counterparts. The response of the animals to repeated testing seemed to be both sex and treatment dependent. In both males and females, NALTX treatment during the preweanling period did not affect locomotor activity, but increased the animals' levels of anxiety and emotionality and decreased exploratory behavior. Our results indicate that neonatal opioids may play an important role in the development of behavioral responses in the adult. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Pharmacology Biochemistry and Behavior Elsevier

Neonatally administered naltrexone affects several behavioral responses in adult rats of both genders

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Publisher
Elsevier
Copyright
Copyright © 1995 Elsevier Ltd
ISSN
0091-3057
eISSN
1873-5177
DOI
10.1016/0091-3057(94)00314-9
Publisher site
See Article on Publisher Site

Abstract

The effects of a daily injection of the opioid antagonist naltrexone (NALTX, 1 mg/kg SC), from birth to weaning day, on several behavioral parameters were investigated in adult rats of both genders. This work uses three behavioral tests. The use of the open-field test in addition to the holeboard and plus-maze tests allows the measurement of complementary parameters, and provided further information on diverse components of behavior. The effect of repeated testing (habituation) over 3 consecutive days of open-field testing was also assessed. In accordance with previous reports, female rats showed higher locomotor activity and exploration and a lower level of emotionality than their male counterparts. The response of the animals to repeated testing seemed to be both sex and treatment dependent. In both males and females, NALTX treatment during the preweanling period did not affect locomotor activity, but increased the animals' levels of anxiety and emotionality and decreased exploratory behavior. Our results indicate that neonatal opioids may play an important role in the development of behavioral responses in the adult.

Journal

Pharmacology Biochemistry and BehaviorElsevier

Published: Feb 1, 1995

References

  • Exploration, distraction and habituation in rats reared in isolation
    File, S.E.
  • The ontogeny of exploration in the rat: Habituation and effects of handling
    File, S.E.
  • Validity of head-dipping as a measure of exploration in a modified hole-board
    File, S.E.; Wardill, A.G.
  • Emotionality in male and female rodents: A reply to Archer
    Gray, J.A.
  • The use of a plus-maze to measure anxiety in the mouse
    Lister, R.G.

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