Needle-free vaccine delivery

Needle-free vaccine delivery The search for methods of vaccine delivery not requiring a needle and syringe has been accelerated by recent concerns regarding pandemic disease, bioterrorism, and disease eradication campaigns. Needle-free vaccine delivery could aid in these mass vaccinations by increasing ease and speed of delivery, and by offering improved safety and compliance, decreasing costs, and reducing pain associated with vaccinations. In this article, we summarize the rationale for delivery of needle-free vaccines and discuss several methods currently in use and under development, focusing on needle-free injection devices, transcutaneous immunization, and mucosal immunization. Jet injectors are needle-free devices that deliver liquid vaccine through a nozzle orifice and penetrate the skin with a high-speed narrow stream. They generate improved or equivalent immune responses compared with needle and syringe. Powder injection, a form of jet injection using vaccines in powder form, may obviate the need for the “cold chain.” Transcutaneous immunization involves applying vaccine antigen and adjuvant to the skin, using a patch or “microneedles,” and can induce both systemic and mucosal immunity. Mucosal immunization has thus far been focused on oral, nasal, and aerosol vaccines. Promising newer technologies in oral vaccination include using attenuated bacteria as vectors and transgenic plant “edible” vaccines. Improved knowledge regarding the immune system and its responses to vaccination continues to inform vaccine technologies for needle-free vaccine delivery. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Advanced Drug Delivery Reviews Elsevier

Needle-free vaccine delivery

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Publisher
Elsevier
Copyright
Copyright © 2006 Elsevier B.V.
ISSN
0169-409x
D.O.I.
10.1016/j.addr.2005.12.003
Publisher site
See Article on Publisher Site

Abstract

The search for methods of vaccine delivery not requiring a needle and syringe has been accelerated by recent concerns regarding pandemic disease, bioterrorism, and disease eradication campaigns. Needle-free vaccine delivery could aid in these mass vaccinations by increasing ease and speed of delivery, and by offering improved safety and compliance, decreasing costs, and reducing pain associated with vaccinations. In this article, we summarize the rationale for delivery of needle-free vaccines and discuss several methods currently in use and under development, focusing on needle-free injection devices, transcutaneous immunization, and mucosal immunization. Jet injectors are needle-free devices that deliver liquid vaccine through a nozzle orifice and penetrate the skin with a high-speed narrow stream. They generate improved or equivalent immune responses compared with needle and syringe. Powder injection, a form of jet injection using vaccines in powder form, may obviate the need for the “cold chain.” Transcutaneous immunization involves applying vaccine antigen and adjuvant to the skin, using a patch or “microneedles,” and can induce both systemic and mucosal immunity. Mucosal immunization has thus far been focused on oral, nasal, and aerosol vaccines. Promising newer technologies in oral vaccination include using attenuated bacteria as vectors and transgenic plant “edible” vaccines. Improved knowledge regarding the immune system and its responses to vaccination continues to inform vaccine technologies for needle-free vaccine delivery.

Journal

Advanced Drug Delivery ReviewsElsevier

Published: Apr 20, 2006

References

  • Transcutaneous immunization
    Glenn, G.; Kenney, R.T.
  • A practical assessment of transdermal drug delivery by skin electroporation
    Prausnitz, M.R.
  • Macroflux microprojection array patch technology: a new and efficient approach for intracutaneous immunization
    Matriano, J.A.; Cormier, M.; Johnson, J.; Young, W.A.; Buttery, M.; Nyam, K.; Daddona, P.E.
  • Chitosan as a novel nasal delivery system for vaccines
    Illum, L.; Jabbal-Gill, I.; Hinchcliffe, M.; Fisher, A.N.; Davis, S.S.
  • Immunomodulators and delivery systems for vaccination by mucosal routes
    Ryan, E.J.; Daly, L.M.; Mills, K.H.

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