We addressed the question of whether (+)-5-methyl-10,11-dihydro-5 H -dibenzo( a,d )cyclohepten-5,10-imine (MK-801) and dl -( E )2-amino-4-methyl-5-phosiphono-3-pentenoic acid (CGP37849), a non-competitive and a competitive N -methyl- d -aspartate (NMDA) receptor antagonist, respectively, are able to block morphine-induced conditioned place preference (CPP). MK-801 alone (0.1 mg/kg) produced neither a place preference nor a place aversion, but was able to completely block morphine-induced CPP. CGP37849 alone (10 mg/kg) produced a small but significant CPP, and was able to significantly attenuate morphine-induced CPP These results cannot be due to simple additive effects of drug actions, but suggest that NMDA receptors play a complex role in the development of morphine CPP.
Neuroscience Letters – Elsevier
Published: Jun 23, 1995
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