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during bioprocessing, such as protein N - glycosylation , a critical quality attribute for most monoclonal antibody (mAb) therapeutics . Glycosylation of mAbs is known to influence their efficacy ...
bioprocessing, such as protein N - glycosylation , a critical quality attribute for most monoclonal antibody (mAb) therapeutics . Glycosylation of mAbs is known to influence their efficacy as therapeutics ...
N ‐linked glycosylation is known to be a crucial factor for the therapeutic efficacy and safety of monoclonal antibodies (mAbs) and many other glycoproteins. The nontemplate process of glycosylation ...
ABSTRACT N ‐linked glycan distribution affects important end‐use characteristics such as the bioactivity and efficacy of many therapeutic proteins, (including monoclonal antibodies), in vivo. Yet ...
Monoclonal antibodies (mAbs) are one of the most important products of the biopharmaceutical industry. Their therapeutic efficacy depends on the post‐translational process of glycosylation , which ...
Core fucosylation is a highly prevalent and significant feature of N ‐ glycosylation in therapeutic monoclonal antibodies produced by mammalian cells where its absence (afucosylation) plays a key role ...
Glycosylation is a critical quality attribute of therapeutic monoclonal antibodies (mAbs). The glycan pattern can have a large impact on the immunological functions, serum half‐life and stability ...
of therapeutic monoclonal antibodies (mAbs). As the biopharmaceutical market for these biologics and their biosimilars is rapidly growing, the role of SPR biosensors in drug discovery and quality assessment ...
N ‐linked Fc glycosylation of IgG1 monoclonal antibody therapeutics can directly influence their mechanism of action by impacting IgG effector functions such as antibody‐dependent cell‐mediated ...
type N - glycosylation (Strasser et al. 2004). In conclusion if plants are used to produce therapeutic antibodies and the transferases are not silenced, β1,2-xylose and α1,3-fucose should be taken ...
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