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N 1 -Dansyl-spermine: a potent polyamine antagonist

The potential polyamine antagonist action of N 1 -dansyl-spermine (a potent NMDA antagonist) was assessed in two in vivo mouse models of polyamine action. Co-administration of N 1 -dansyl-spermine (2–10 μg, i.c.v.) with spermine (100 μg, i.c.v.) resulted in a dose-dependent antagonism of the spermine-induced CNS excitation (body tremor and fatal tonic convulsions). In addition, the same dose of N 1 -dansyl-spermine antagonised spermine's enhancement of NMDA-induced convulsions. These results suggest that N 1 -dansyl-spermine is in vivo a potent antagonist of the CNS effects of spermine and of its action at the positive polyamine modulatory site on the NMDA receptor. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Brain Research Elsevier
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