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rationale and the results of initial studies of the therapeutic effects of PDE5 inhibition in HF. The Emerging Role for Type 5 Phosphodiesterase Inhibition in Heart Failure Gregory D. Lewis, MD, and Marc J ...
Protective effect of phosphodiesterase 5 ( PDE5 ) inhibitor sildenafil on hypoxic injury of isolated myocardial cells and its mechanism of action were investigated. Myocardial cells of neonatal mice ...
) by inhibition of phosphodiesterase-5 ( PDE5 ) is a relatively new, but promising therapeutic strategy. Preclinical studies suggest a favorable myocardial effect of PDE5 inhibitors by blocking adrenergic ...
the effects of PDE5 inhibition with sildenafil in dogs with CHF produced by rapid ventricular pacing. CHF resulted in decreases of left ventricular (LV) systolic pressure, coronary blood flow, and the maximal ...
ventricles. PDE5 inhibitor amelio- Clating numerous cellular functions. In the cardiac myo- rates cardiac hypertrophy in mice, and genetic silencing of cyte, cGMP mediates effects of nitric oxide and atrial ...
efficacious in the pulmonary than in the systemic vasculature, for which reason they are used principally in patients with pulmonary hypertension. Effects attributable to inhibition of myocardial PDE5 activity ...
increasing cGMP levels resulting from inhibition of PDE5 . Objective: Celecoxib carries a smaller cardiovascular risk for myocardial infarction and hypertension than other cyclooxygenase-2 (COX-2)- selective ...
) inhibition has been shown to exert profound beneficial effects in the failing heart, suggesting a significant role for PDE5 in the development of congestive heart failure (CHF). The purpose of this study ...
for the pulmonary circulation. Basic studies suggest that increased cGMP activity by PDE5 inhibition has potentially favorable direct myocardial effects that may block adrenergic, hypertrophic, and proapoptotic ...
the effects of sildenafil, a phosphodiesterase‐5 ( PDE5 ) inhibitor elevating c‐GMP, on myocardial hypertrophy and function in rats with RV hypertrophy. Methods: Rats were pulmonary trunk banded (PTB ...
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