Mutations in matrix protein 1 and nucleoprotein caused human-specific defects in nuclear exportation and viral assembly of an avian influenza H7N1 virus

Mutations in matrix protein 1 and nucleoprotein caused human-specific defects in nuclear... •Human-specific replication defects of an avian influenza virus were identified.•The defects might be involved in avian influenza virus adaptation to human host.•Nuclear export and RNP assembly impairments were responsible for the defects.•M1 and NP mutations were identified as the genetic determinants of the defects. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Virus Research Elsevier

Mutations in matrix protein 1 and nucleoprotein caused human-specific defects in nuclear exportation and viral assembly of an avian influenza H7N1 virus

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Publisher
Elsevier
Copyright
Copyright © 2017 Elsevier B.V.
ISSN
0168-1702
D.O.I.
10.1016/j.virusres.2017.05.021
Publisher site
See Article on Publisher Site

Abstract

•Human-specific replication defects of an avian influenza virus were identified.•The defects might be involved in avian influenza virus adaptation to human host.•Nuclear export and RNP assembly impairments were responsible for the defects.•M1 and NP mutations were identified as the genetic determinants of the defects.

Journal

Virus ResearchElsevier

Published: Jun 15, 2017

References

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